American College of Cardiology

Adipokine Hypothesis Revolutionizes Understanding of Heart Failure with Preserved Ejection Fraction

New research presents a groundbreaking hypothesis suggesting that excess internal fat tissue, rather than comorbidities, is the leading cause of heart failure with preserved ejection fraction (HFpEF). Dr. Milton Packer's Adipokine Hypothesis proposes that changes in the biology of internal fat tissue release transformed adipokine molecules, promoting stress,