Antibodies
Researchers at the University of Paris have made significant progress in diagnosing past COVID-19 infections using a combination of T-SPOT assays and antibody tests. The study aimed to evaluate the efficacy of T-SPOT assays in detecting cell-mediated immune responses against SARS-CoV-2. The findings suggest that integrating cellular and humoral immunity
Biological products
Lava Therapeutics N.V. has been issued a patent for a novel antibody that targets prostate-specific membrane antigen (PSMA) and can stimulate autologous Vg9Vd2 T cells to kill prostate cancer cells. The patent, titled "Antibodies that bind PSMA and gamma-delta T cell receptors," was filed on May 6,
Biological products
Chinese pharmaceutical company Jiangsu Hengrui Medicine Co. Ltd. has been issued a patent for an anti-Claudin 18.2 antibody by the United States Patent and Trademark Office. The patent, filed on March 31, 2020, was published online on September 30, 2025, under the patent number 12428478. The inventors of the
Biological products
The patent titled "Anti-TREM2 Antibodies and Related Methods" has been published online on September 30, 2025. The inventors, Aritra Pal, Leonard G. Presta, Venkataraman Sriram, Michel Streuli, and the assignee Portsmouth Merger Sub II LLC, describe an isolated antibody that binds to human TREM2 and competes with the
Biological products
Chinese pharmaceutical company Jiangsu Hengrui Medicine Co. Ltd. has been issued a patent for an anti-Claudin 18.2 antibody by the United States Patent and Trademark Office. The patent, filed on March 31, 2020, was published online on September 30, 2025, under the patent number 12428478. The inventors of the
Biological products
Lava Therapeutics N.V. has been issued a patent for a novel antibody that targets prostate-specific membrane antigen (PSMA) and can stimulate autologous Vg9Vd2 T cells to kill prostate cancer cells. The patent, titled "Antibodies that bind PSMA and gamma-delta T cell receptors," was filed on May 6,
Antibodies
A breakthrough study has been published in the quest for a more effective HIV vaccine. Co-led by the Batista Lab at the Ragon Institute and Scripps/IAVI, the research shows that a single mRNA-based vaccine mix can stimulate several promising HIV-fighting antibodies at once. This approach has the potential to
Antibodies
A 60-year-old man presented with progressive dyspnea, and echocardiography demonstrated left ventricular hypokinesis with an ejection fraction of 40%. He was later diagnosed with antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis (EGPA), a chronic inflammatory condition characterized by eosinophilic infiltration of multiple organ systems. The patient's cardiac involvement
Biological products
JSKN003, a biparatopic anti-HER2 antibody-drug conjugate, has demonstrated promising efficacy in treating primary platinum-refractory ovarian cancer, HER2-positive metastatic colorectal cancer, and platinum-resistant ovarian cancer, according to data presented at the 2025 European Society for Medical Oncology Congress. The therapy showed a significant response rate, disease control rate, and overall survival
Biological products
Recent breakthroughs in developing anti-CD19 antibodies and multi-specific binding proteins are gaining momentum in the fight against cancer. Researchers from Cullinan Therapeutics Inc. have filed a patent for a groundbreaking invention that combines the potency of BiTE constructs with the convenience of longer-lasting treatments. The new antibodies and proteins have
Biological products
Researchers at Crystal Bioscience Inc. have developed a transgenic chicken that produces antibodies with long CDR3 regions, a significant breakthrough in the field of immunology. The chicken's genome has been engineered to include functional immunoglobulin heavy chain genes, which encode for antibodies with long CDR3 regions. This innovation
Antibodies
Researchers at Guangzhou Medical University have made a significant discovery in the field of thrombocytopenia, a condition characterized by low platelet count in the blood. Through their study, they found that anti-HLA antibodies bound to monocytes can alter antibody-mediated platelet phagocytosis, leading to mild thrombocytopenia. The researchers pretreated whole blood
