Cancer research
A new study has shed light on the effective localization of the sentinel lymph node (SLN) in tongue carcinoma using a combination of indirect computed tomography lymphography (CT-LG) with methylene blue dye injection. The research, conducted by H. Wu and colleagues at Fudan University in Shanghai, People's Republic
Cancer treatment
Recent research from the United States has shed light on the mechanisms underlying histone deacetylase inhibitor (HDACI)-mediated NF-kappaB activation in human leukemia cells. The study, conducted by R.R. Rosato and colleagues from Virginia Commonwealth University, Department of Medicine, investigated the effects of LBH-589, a histone deacetylase inhibitor, on
Cancer treatment
A new approach to breast cancer therapy has been developed using a modified human telomerase reverse transcriptase (hTERT) promoter-directed oncolytic adenovirus that targets the TGFbeta pathway. Researchers from Northwestern University have created a virus, mhTERTAd.sTbetaRFc, that replicates in breast cancer cells while inhibiting TGFbeta signaling. The study demonstrates the
Cancer treatment
Researchers have made significant progress in understanding the role of the histone methyltransferase DOT1L in the development and transformation of leukemia. According to a study published in Expert Opinion On Therapeutic Targets, DOT1L is responsible for methylation of histone H3 at lysine 79 and is involved in the pathobiology of
Cancer research
Researchers from the National Defense Medical Center in Taipei, Taiwan, have reported a dramatic success in treating a metastatic brain tumor using CyberKnife stereotactic radiosurgery. The case involved an adenocarcinoma of the lung that had spread to the brain, with a tumor diameter of approximately 3 cm. Despite previous treatments,
Cancer treatment
Malignant gliomas, including glioblastoma multiforme (GBM) and anaplastic astrocytomas, are the most common primary brain tumors. Despite multimodal treatment including surgery, chemotherapy, and radiation, median survival for patients with GBMs is only 12 to 15 months. Identifying molecules critical for glioma progression is crucial for devising effective targeted therapy. Researchers
Cancer research
Researchers at the University of Texas M.D. Anderson Cancer Center have made a significant discovery in the field of melanoma treatment. By targeting inducible nitric oxide synthase (iNOS), they found that it can inhibit the growth of human melanoma in vivo and synergize with chemotherapy. The study, published in
Cancer research
The National Cancer Institute (NCI)-sponsored Phase 1/2 trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide for the first-line treatment of advanced or recurrent thymic malignancies has begun dosing patients. This trial aims to determine the safe doses of the combination therapy in patients and provide recommendations
Cancer treatment
A compound isolated from the golden berry, Physalis peruviana, has been found to inhibit the growth of human lung cancer cells through DNA damage, apoptosis, and G2/M arrest. The study, published in BMC Cancer, demonstrates that the compound, 4beta-Hydroxywithanolide E (4betaHWE), has potential as a chemotherapeutic agent against lung
Cancer research
Researchers in Vancouver, Canada, have made significant progress in developing personalized chemotherapy for non-small cell lung cancer (NSCLC) patients. Their study, published in Clinical Cancer Research, presents promising data on patient-derived first-generation xenografts as tools for predicting drug responses. This breakthrough has the potential to revolutionize the treatment of NSCLC,
Cancer treatment
Researchers at the University of KwaZulu-Natal in Durban, South Africa, have made a significant discovery in the field of cancer research. Studying small cell lung cancer (SCLC), an aggressive tumor type that often leads to ectopic ACTH syndrome, the team found that over-expression of the glucocorticoid receptor (GR) promotes apoptosis
Cancer treatment
Researchers from Tianjin University in the People's Republic of China have developed a novel co-delivery system that significantly improves the cytotoxicity of 5-fluorouracil (5-FU) and enhances the apoptosis of human glioblastoma cells. The system utilizes poly(amidoamine) (PAMAM) dendrimer to co-deliver antisense-miR-21 oligonucleotide (as-miR-21) and 5-FU to human
