Diseases
A recent study published in Cell Reports has shed light on the mechanisms underlying primary Sjögren disease, a chronic autoimmune disorder. The research, conducted by a team of scientists from the University of Hong Kong, has identified a novel role for caveolin-1 (Cav-1) in suppressing the expression of inducible T
B cells
Fresh data on Parasitic Diseases and Conditions - Echinococcosis have been presented in a new report from Ningxia Medical University in Yinchuan, People's Republic of China. According to the research, alveolar echinococcosis (AE) is a zoonotic parasitic disease that poses a grave threat to human health, and recent
Autoimmunity
A recent study published in Cell Reports has shed light on the mechanisms underlying primary Sjögren disease, a chronic autoimmune disorder. The research, conducted by a team of scientists from the University of Hong Kong, has identified a novel role for caveolin-1 (Cav-1) in suppressing the expression of inducible T
Gene therapy
Gene therapy for Severe Combined Immunodeficiency (SCID), a rare inherited immune disorder, has faced significant challenges, particularly for RAG-deficient SCID. However, a recent patent filing by Laura Garcia-Perez, Arjan C. Lankester, Karin Pike-Overzet, Frank J. T. Staal, and Marja C. J. A. Van Eggermond from the Academy Hospital Leiden (H.
B cells
Scientists from the Institut Pasteur and Inserm have successfully reprogrammed the death of malignant B cells to stimulate an effective anti-tumor immune response, paving the way for a potential therapeutic avenue for certain cancers, including lymphomas and leukemias. By combining three existing drugs, researchers were able to induce necroptosis, a
Autoimmunity
Researchers at the University of Birmingham have made a groundbreaking discovery in the field of immunology, revealing that lactate signalling plays a crucial role in the aggregation of immune-inflammatory hotspots in autoimmune diseases. According to their study, published in Nature Metabolism, lactate is a master regulator of ectopic lymphoid structures
Autoimmunity
Researchers at the University of Birmingham have made a groundbreaking discovery in the field of immunology, revealing that lactate signalling plays a crucial role in the aggregation of immune-inflammatory hotspots in autoimmune diseases. According to their study, published in Nature Metabolism, lactate is a master regulator of ectopic lymphoid structures
Antiviral agents
Researchers have made a significant breakthrough in understanding the treatment of severe COVID-19, with a recent study revealing the effectiveness of the MEK inhibitor zapnometinib in reducing viral load and alleviating lung pathology in hospitalized patients. The study, conducted by researchers at Eberhard-Karls University in Tuebingen, Germany, demonstrated that zapnometinib
Antibodies
Researchers at the University of Cologne, led by Dr. Lutz Gieselmann, have made a significant discovery in the fight against HIV. An antibody called 04_A06 has been found to neutralize 98.5% of over 300 different HIV strains, making it one of the broadest antibodies against HIV identified. This
B cells
Multiple sclerosis patient Emily Henders, 37, has become the first person in the UK to receive CAR T-cell therapy to treat the condition. Henders, a biology teacher, was diagnosed with multiple sclerosis on Christmas Eve in 2021 and has since experienced four debilitating relapses. Despite taking one of the most
Atherosclerosis
Researchers from Northwestern University Feinberg School of Medicine have published a study on the associations of immune cell subsets with longitudinal changes in subclinical coronary artery disease. The study used data from the Multi-Ethnic Study of Atherosclerosis (MESA) and examined the relationships between 28 immune cell subsets and changes in
B cells
A recent study published by researchers at Yale University School of Medicine has shed new light on the development of B cell lymphopoiesis in the small intestine during fetal and neonatal life. The study finds that the small intestine is a potential site for B cell lymphopoiesis, but the unique
