Genes
Research by investigators from Wuhan University has shed new light on the pathogenesis of odontogenic keratocyst (OKC), an aggressive jaw lesion characterized by high recurrence rates. By analyzing transcriptomic data from non-syndromic OKC and normal oral mucosa samples, the study identified differentially expressed basement membrane-related genes (BM DEGs) and pinpointed
Antibodies
A breakthrough study has been published in the quest for a more effective HIV vaccine. Co-led by the Batista Lab at the Ragon Institute and Scripps/IAVI, the research shows that a single mRNA-based vaccine mix can stimulate several promising HIV-fighting antibodies at once. This approach has the potential to
Antibodies
Research from the University of Science and Technology of China has led to the development of self-adjuvant-effect biomimetic nanovaccines capable of counteracting current and prospective viral variants of SARS-CoV-2. This innovative approach utilizes synthetic biology technology to create nanoparticles that significantly promote the recruitment of dendritic cells to secondary lymphoid
B cells
Researchers at Preclina Inc. in Seoul, South Korea, have published a study on a new humanized mouse model for pulmonary fibrosis, a progressive lung disease characterized by excessive extracellular matrix deposition. According to the study, conventional preclinical models are unsuitable for evaluating human-specific antibody and cell therapies due to their
B cells
A study published in Frontiers in Immunology has uncovered the complex immune cell architecture responsible for HIV control in a subset of individuals known as HIV controllers. Researchers from Radboud University Medical Center in Nijmegen, Netherlands, analyzed immune cells from 54 HIV controllers, including 21 elite controllers, and compared them
Asian medicine
Researchers from Henan University of Chinese Medicine have made a breakthrough discovery in the treatment of acute lung injury (ALI), a severe inflammatory disorder with a high morbidity and mortality rate. According to their study, urolithin A (UA) exhibits anti-inflammatory and anti-oxidative effects in ALI, suggesting its potential as a
Infection
The human gut microbiota plays a crucial role in overall health, and alterations to this delicate balance can have significant effects on our wellbeing. Research has long suggested that human herpesviruses (HHVs), which are ubiquitous in most populations by the eighth decade of life, may be linked to various neurodegenerative
B cells
Data from a prospective observational study conducted at the Arnau de Vilanova Hospital in Valencia, Spain, has revealed significant insights into the immune response of breast cancer patients undergoing active treatment. The research, focusing on the immunogenicity of SARS-CoV-2 mRNA vaccine in this population, demonstrated a strong humoral response with
B cells
Actuate Therapeutics, a clinical-stage biopharmaceutical company, has announced the completion of the Phase 1 portion of its clinical study evaluating elraglusib monotherapy or in combination with other treatments in pediatric patients with refractory malignancies. The study, which enrolled ten patients with relapsed/refractory Ewing Sarcoma, has yielded promising results, with
B cells
New research out of Kyung Hee University in Seoul, South Korea, has shed light on a novel approach to influenza vaccine delivery, indicating that orally dissolving films (ODFs) may be a more effective method than traditional oral administration. This innovative strategy leverages the mucosal immune system to stimulate a robust
B cells
Researchers at the Department of Oncology and Hematology have published new findings on the relationship between COVID-19 mRNA-based vaccines and the risk of thromboembolic events in cancer patients undergoing active treatment. The study, which analyzed data from November 2021 to October 2022, found that cancer patients have no increased risk
