Genetic research
Research has shed new light on the importance of maternal nutrition during pregnancy, with a study exploring the epigenetic link between maternal dietary protein intake and preterm birth (PTB). The study, conducted among Karen and Burmese populations in Myanmar and Thailand, analyzed DNA methylation in placental and cord blood samples
Genetic research
Researchers at the Boyce Thompson Institute have made a significant discovery in the field of plant proteins. By combining a double gene construct harboring Cry2Ab and PTA, they have achieved broad-spectrum and durable resistance against multiple insect pests. The study, published in Molecular Biology Reports, demonstrates the efficacy of the
Genetic research
A study published in PeerJ has shed light on the epigenetic mechanisms contributing to pregnancy failure in recurrent miscarriage (RM). Research conducted by a team of scientists from the Affiliated Hospital of Guangdong Medical University in Zhanjiang, People's Republic of China, revealed that RM samples exhibited significant epigenetic
Genetic research
Research conducted at Xuzhou Central Hospital in Jiangsu, People's Republic of China, has led to a significant advancement in serotonin detection. A team of scientists has designed a novel self-quenching electrochemiluminescence (ECL) biosensor based on DNA tetrahedral nanostructures (DTNs)-enhanced catalytic hairpin assembly (CHA) to accurately detect serotonin
Antigenic determinants
Researchers at Huazhong University of Science and Technology have developed DNA vaccines encoding the spike protein of both the ancestral virus and Omicron variants, which demonstrated strong cross-reactive T cell responses in mice. The study found that only a limited number of mice vaccinated with the DNA vaccine targeting the
Adenocarcinoma
Fresh data on Oncology - Lung Cancer have been presented in a new report, highlighting the pivotal role of lymph node metastasis in determining prognosis in lung adenocarcinoma. Researchers from Tianjin Medical University employed single-cell RNA sequencing to compare metastatic and non-metastatic lymph nodes, uncovering metastasis-associated immune and stromal alterations.
Diseases
Researchers at the University of Putra Malaysia have made a significant breakthrough in breeding chili peppers to be more resilient to diseases and heat stress. According to the study, published in Euphytica, the team successfully transferred genes for disease resistance and heat tolerance to superior chili hybrids, enhancing their ability
Diseases
Research has shown that ferroptosis, a distinct form of regulated cell death, plays a critical role in various systemic diseases, including cancer, cardiovascular disease, and neurological disorders. According to a new study published in the journal Frontiers in Cell and Developmental Biology, high-mobility group box 1 (HMGB1) is a key
Diseases
Research has highlighted the importance of sustainable and effective disease management strategies in global aquaculture, as viral diseases inflict severe economic losses. Current conventional chemical treatments are limited by environmental concerns, antibiotic resistance, and scarcity of specific antivirals. RNA interference (RNAi) has emerged as a promising antiviral strategy, utilizing synthetic
Diseases
Scientists at Duke University have made significant progress in developing a gene therapy approach for glycogen storage disease type III (GSD III) using a recombinant adeno-associated virus serotype 9 (AAV9) vector. This innovative therapy, which expresses a bacterial debranching enzyme (pullulanase) driven by a tandem dual promoter, has shown long-term
Biochemistry
A recent study published in Signal Transduction and Targeted Therapy has revealed that influenza A virus (IAV) induces PANoptosis, a form of lytic inflammatory cell death, in macrophages. The research, conducted by a team of scientists at the China-Japan Friendship Hospital, found that Ninjurin-1 (NINJ1), a mediator of plasma membrane
Biochemistry
Research conducted at the Institute for Biomedical Engineering in Tianjin, China, has led to the development of nanoparticles that can reprogram tumor-associated macrophages to fight cancer. The study, published in Biomaterials Science, shows that the nanoparticles can induce immunogenic cell death of tumor cells, activate dendritic cells, and initiate T
