Biotechnology
Scientists from Inner Mongolia Agricultural University in Hohhot, People's Republic of China, have published a comprehensive review on the impact of high-concentrate diets on lambs' gut health, highlighting the potential benefits of plant extracts in enhancing intestinal barrier function. The research, published in Science - Animal Bioscience,
Cancer treatment
Researchers in Chengdu, People's Republic of China, have discovered a new strategy for overcoming tumor resistance, offering a promising therapeutic outcome for cancer patients. The innovative dual-payload antibody-drug conjugate (ADC) platform integrates exatecan and triptolide to enhance antitumor efficacy and overcome resistance. This groundbreaking research has been peer-reviewed
Biochemistry
Researchers at Yale University School of Medicine have made significant progress in cancer gene therapy by developing a novel delivery system for triplex-forming oligonucleotides (TFOs). The study, published in Molecular Therapy - Nucleic Acids, utilized a lupus-derived anti-DNA monoclonal antibody, 3E10, to target and deliver TFOs into the nucleus of
Biological products
Researchers from Tanta University have made significant strides in the field of regenerative therapies using novel biomaterials. In a recent study published in the Journal of Oral Biology and Craniofacial Research, researchers evaluated the effectiveness of biologically compatible scaffolds in repairing periodontal and bony defects. The study found that b-tricalcium
Biological markers
Researchers from Chulalongkorn University in Bangkok, Thailand, have made a significant breakthrough in understanding the reproductive physiology of canines, particularly in the area of oocyte maturation. The study, utilizing shotgun proteomics, identified 11 proteins that are upregulated during the periovulatory period, which could serve as potential biomarkers of oocyte maturation.
Biotechnology
New research out of the Federal University of Ceara in Brazil has highlighted the potential of lectins as antiviral agents and diagnostic tools in the fight against coronavirus and other viral pathogens. The study, published in the journal ACS Bio & Med Chem Au, explores the molecular interactions between lectins
3D printing
Researcher Parisa Khodabakhshi, an assistant professor of Mechanical Engineering and Mechanics at Lehigh University's P.C. Rossin College of Engineering and Applied Science, has received a $350,000 grant from the National Science Foundation to develop a computationally efficient model that accurately predicts how additive manufacturing process parameters
Biological products
A new study published in the journal Vaccine has highlighted the need for personalized vaccination strategies to optimize protection in patients with autoimmune inflammatory rheumatic diseases (AIRDs). Researchers from the Graduate School of Medicine identified distinct antibody response trajectories in patients with AIRDs, including a subgroup with persistently low humoral
Biological products
New research conducted by Anandie le Roux and colleagues at North-West University in Potchefstroom, South Africa, has identified several small molecule therapeutics (SMTs) that demonstrate the potential to treat snakebite envenoming. According to the study, these SMTs have shown efficacy in preclinical models of snakebite envenoming, with varespladib being granted
Antioxidants (Nutrients)
A team of researchers from the University of Turin has conducted a study to investigate the antioxidant potential of pomegranate leaf extract and its derivatives. The study involved testing the extract's ability to protect human dermal fibroblast and human umbilical vein endothelial cells from oxidative stress. The results
Biological products
The FDA has granted fast track designation to HDP-101, an investigational antibody drug conjugate (ADC), as a therapy for patients with multiple myeloma. This decision was based on supporting data from nonclinical findings and clinical data from an ongoing phase 1/2a study (NCT04879043). The study, led by Dr. Shambavi
Apoptosis
Researchers have made significant progress in understanding the immunogenicity of tislelizumab, a humanized anti-PD-1 antibody, which has been analyzed in a comprehensive study involving 3815 patients. The investigation focused on the incidence of anti-drug antibodies (ADAs) and the feasibility of assessing the suitability of validation cut points (VCPs) using statistical
