Immunology
Pulmonary Delivery of Chitosan-DNA Nanoparticles Enhances Immunogenicity of TB Vaccine
Researchers have discovered that delivering DNA vaccines via the pulmonary route, utilizing chitosan-DNA nanoparticles, significantly enhances immunogenicity against Mycobacterium tuberculosis. The study, conducted at the Leiden/Amsterdam Center for Drug Research and Leiden University, utilized an HLA-A2 transgenic mouse model to investigate the effects of pulmonary delivery of a new