Alzheimer's disease
As we age, the risks of neurodegenerative disorders like Alzheimer's disease rise, and the brain's volume shrinks in size, losing both grey and white matter over time. A recent study published in PNAS on October 13, 2025, has revealed that the brain's shrinking pace
Diseases
New research has discovered that men's brains shrink faster than women's, contrary to the higher diagnosis rates of Alzheimer's disease among women. The study, published in the Proceedings of the National Academy of Sciences, analyzed over 12,000 brain MRIs from nearly 5,000
RNA
Research from the Icahn School of Medicine at Mount Sinai has shed light on the complex relationship between living and postmortem human brain tissues. Due to the unavailability of living human brain tissue for molecular research, postmortem brain samples are currently the standard tissue source for molecular studies of the
Brain
Recent research on neuropathology, led by investigators at the University of Iowa, has shed light on the impact of seizures on developing brain circuits. The study, published in Acta Neuropathologica Communications, reveals that excessive glutamate receptor activation during seizures can cause widespread dendritic beading, a condition characterized by varicose dendritic
Alzheimer's disease
A team of researchers from the University of Cambridge has made significant progress in developing potent and selective inhibitors of the NUAK1 protein kinase, a key player in various cellular functions including cell proliferation, migration, and adhesion. This research, funded by Alzheimer's Research UK (ARUK) and the ALBORADA
Brain
Denise Bacon, a 65-year-old woman with Parkinson's disease, underwent deep brain stimulation (DBS) surgery at King's College Hospital in London to alleviate symptoms of the condition. To help surgeons assess the immediate effect of the procedure on her motor function, Ms. Bacon played the clarinet during
Diseases
A groundbreaking international study has found that women with a precursor condition to Parkinson's disease, known as isolated REM sleep behavior disorder, exhibit significantly less brain atrophy than men, despite similar clinical severity. The research, involving nearly 700 participants from nine international centers, reveals that women show remarkable
Nervous system diseases
Research at the Salk Institute for Biological Studies in La Jolla, California, has shed new light on the mechanisms underlying co-occurrence of metabolic symptoms and neuropsychiatric disorders, such as bipolar disorder. The study, published in Nature Neuroscience, found that individuals with bipolar disorder have insulin secretion deficits caused by increased
Nervous system diseases
Research published in the journal Experimental Neurology has shed new light on the relationship between blood-brain barrier damage and cognitive impairment in dementia patients. A team of scientists from Peking University Third Hospital developed an animal model of cerebral small vessel disease (CSVD) using ultrasound-targeted microbubble destruction technology. The study
Nervous system diseases
Researchers at the University of Cologne, led by Ramon Rabii, have conducted a retrospective study of patients admitted to the emergency department (ED) with severe hyponatremia, a condition characterized by low levels of sodium in the blood. The study aimed to determine the risk of cerebral edema and osmotic demyelination
Brain
Liam Vincent-Kilbride, a 31-year-old father from Fife, Scotland, has been left reeling after being told that the National Institute for Health and Care Excellence (Nice) plans to reject the prescription of vorasidenib, a drug that he claims has transformed his life. Liam, who has glioma, a type of incurable brain
Brain
A study conducted by researchers at the University of Occupational and Environmental Health in Fukuoka, Japan, investigated the return-to-work (RTW) rates and associated factors following endoscopic transsphenoidal surgery (eTSS) among patients with pituitary and hypothalamic tumors in Japan. The study aimed to determine the variables affecting early RTW post-surgery. The
