Cancer research
A new study on Oncology has shed light on the role of epigenetic alteration in cancer progression. Researchers at the University of Florida have found that histone methyltransferase hSETD1A is a novel regulator of metastasis in breast cancer. The study revealed that hSETD1A is upregulated in multiple metastatic human breast
Cancer research
PanC-Dx[TM] , a non-invasive diagnostic technology developed by OncoCyte Corporation, a subsidiary of BioTime, Inc., demonstrated potential in identifying malignant breast lesions through a large, prospective clinical study. The study, which has nearly completed enrollment of over 600 patients, aims to assess the performance of PanC-Dx[TM] in distinguishing patients
Cancer research
Researchers have identified that CHEK2 gene mutations are rare among high-risk breast cancer patients in Malaysia, suggesting a minor contributing role in breast carcinogenesis among the Malaysian population. The study analyzed 59 high-risk breast cancer patients who tested negative for BRCA1/2 germline mutations and found two missense mutations in
Cancer research
A recent study published in Tumor Biology has found a significant association between higher circulating levels of chemokine CCL22 and breast cancer in patients. The study, conducted by researchers at Shiraz University of Medical Sciences, aimed to evaluate the serum CCL22 levels and a single nucleotide polymorphism (SNP) in the
Cancer research
Researchers have identified several single-nucleotide polymorphisms (SNPs) that are associated with the response of breast cancer patients to neoadjuvant chemotherapy. The study used cell line panels and genotyped a subset of patients included in a neoadjuvant breast cancer trial to explore the relationship between genotypes and clinical outcome according to
Cancer research
A new study has shed light on the potential treatment of triple-negative breast cancer, a subtype that accounts for 20% of all molecular subtypes of breast cancer. Researchers at the University of Jinan-Shandong Academy of Medical Sciences have found that a combination of recombinant human p53 adenovirus (Ad-p53) and the
Cancer research
Research findings from the University of London suggest that reduced progesterone levels in obese premenopausal women may explain the previously unexplained reduced incidence of breast cancer in this demographic. These findings challenge the conventional understanding that obesity increases the risk of breast cancer in premenopausal women. The study reveals that
Cancer research
Researchers have uncovered the mechanism by which delta EF1 family proteins repress expression of E-cadherin in breast cancer cells, a key feature of cancer progression. According to the study, E-cadherin expression is downregulated in epithelial tumors, leading to reduced levels of the protein. The delta EF1 family proteins, delta EF1/
Cancer research
New research out of Edmonton, Canada, suggests that genome-wide association studies (GWASs) can identify low-penetrance common variants associated with breast cancer susceptibility. While GWASs primarily focus on single-locus effects, gene-gene interactions, or epistasis, are also assumed to contribute to the genetic risks for complex diseases, including breast cancer. Researchers at
Cancer research
Research on breast cancer risk factors has led investigators to discover new associations between alcohol consumption, breast folate concentration, and variation in one-carbon metabolism genes with p16 (INK4a) promoter methylation and P16 protein expression in histologically normal breast tissues. These findings suggest that alcohol consumption may impede folate metabolism, leading
Cancer research
Researchers at the University of Isfahan in Iran have designed a novel chimeric peptide that represents both B and T cell epitopes from the HER2 extracellular domain (HER2 ECD) for potential use in breast cancer vaccines. This peptide was designed to stimulate the immune system directly, making active immunotherapy a
Cancer research
Researchers have found that a targeted approach to lymph node surgery in breast cancer patients can significantly reduce the number of nodes removed, improving accuracy in axillary staging. The study, published in the Annals of Surgical Oncology, compared the efficacy of two methods: sentinel lymph node (SLN) surgery using [Tc-99m]
