Cancer genetics

Cancer

Overcoming Chemoresistance in Non-Small Cell Lung Cancer with Innovative Nanocomposite Hydrogel System

Researchers from Sichuan University have proposed an innovative nanocomposite hydrogel system for the co-delivery of cisplatin and short hairpin RNA (shRNA) targeting protein arginine methyltransferase 5 (PRMT5), a key gene implicated in drug resistance. This system utilizes polyethyleneimine-modified mesoporous silica nanoparticles, which serve as nanocarriers, encapsulating cisplatin within the mesopores

Cancer

Insights into Platelet Biogenesis: Epigenetic Programs Essential for Efficient Platelet Production

Recent research published in Nature Communications has shed light on the epigenetic programs essential for platelet biogenesis. The study, conducted at the University of Texas MD Anderson Cancer Center, focused on the roles of histone lysine methyltransferases MLL3 and MLL4 in regulating gene expression during platelet production. The findings suggest

Cancer research

Breakthrough in Cancer Gene Therapy: Ginsenoside F2-Modified Liposomes Delivering FTY720 Enhance Glioblastoma Targeting and Antitumor Activity

Researchers at Dalian University of Technology, in collaboration with other institutions, have made significant strides in cancer gene therapy, particularly in the treatment of glioblastoma (GBM). According to a recent study published in Phytomedicine, ginsenoside F2-modified liposomes delivering FTY720 have shown enhanced glioblastoma targeting and antitumor activity via ferroptosis. The

Cancer research

Rutin-Containing Cyclodextrin Nanosystems for Dietary Supplementation in Diabetics

Research conducted by the University of Ferrara in Italy has investigated the potential of rutin-containing cyclodextrin nanosystems as a dietary supplement for diabetics. The study, presented in the Journal of Drug Delivery Science and Technology, aimed to address the limitations of rutin's physico-chemical instability and poor solubility in

Cancer

DNA Methylation Profiling Identifies Distinct Clinical and Pathological Subtypes of Pituitary Neuroendocrine Tumors

Research from New York University (NYU) Langone Health has presented fresh data on pituitary neuroendocrine tumors (PitNETs), highlighting their classification challenges and the benefits of using DNA methylation for clinicopathological stratification. The study analyzed clinical, immunohistochemical, and DNA methylation data of 118 PitNETs and developed a clinicomolecular approach to classify

Cancer research

Multimodal Gene Expression and Methylation Profiling Reveals Misclassified Tumors Beyond Histological Diagnosis

Investigators at Thompson Rivers University have published a new report on Cancer, highlighting the importance of integrating gene expression and DNA methylation data to improve tumor classification accuracy and detect misclassified tumors. The research, supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), utilized 6216 samples from

Cancer research

Urea Transporters and Their Gene Mutations Linked to Diseases

Researchers at Chongqing Medical University in Chongqing, People's Republic of China, have made a significant discovery in the field of cancer research, unveiling the crucial role of urea transporters (UTs) in human diseases. The study, published in Sub-cellular Biochemistry, reveals that UT-B and UT-A, encoded by Slc14A1 and

Cancer research

Pancreatic Cancer Research Uncovers Optimal KRAS Mutant Concentration for Prognosis and Monitoring

Investigators at the National Cancer Center in South Korea have published a new study on the clinical significance of circulating tumor DNA (ctDNA) KRAS mutations in patients with pancreatic adenocarcinoma (PAC). The research aimed to propose a cut-off value of mutant KRAS (mKRAS) concentration in ctDNA and validate its clinical

Cancer

Rapid Genome Editing Verification in Human Pluripotent Stem Cells

Researchers at the Sloan Kettering Institute for Cancer Research have developed a rapid and effective workflow for verifying genome-edited human pluripotent stem cells (hPSCs) targeting unexpressed genes using CRISPR-mediated transcriptional activation (CRISPRa). This approach bypasses the need for complex and time-intensive differentiation to induce target gene expression, allowing for the

Cancer

Comprehensive Database for Cancer Research: CanASM

Research has demonstrated that allele-specific DNA methylation (ASM) is critical in understanding the complex genetic and epigenetic mechanisms that regulate gene transcription. Recent studies have shown that ASM is enriched in gene enhancer regions and is increased in cancer tissues compared to normal tissues. A new study has developed CanASM,

Cancer

Immuno-Oncology Recapitulates Ontogeny: Modern Cell and Gene Therapy for Cancer

Pittsburgh, Pennsylvania, a team of researchers from the University of Pittsburgh Medical Center has made a groundbreaking discovery in the field of cancer gene therapy. According to the study, immuno-oncology has evolved significantly over the past century, with the introduction of immune checkpoint blockade (ICB) in the last 15 years

Cancer research

Unlocking the Secrets of Breast Cancer: New Research Aims to Understand Genetic Variation and Protein Regulation

Research by Dr Seyed Mehdi Jafarnejad at Queen's University Belfast has been awarded £314,945 by Breast Cancer Now to investigate the role of the ZFP36L1 protein in breast cancer risk. The study aims to understand why lower levels of this protein increase the risk of breast cancer,