Cancer research
A team of researchers in Copenhagen, Denmark, has published a study in Clinical Cancer Research demonstrating the therapeutic effect of transcriptionally targeted suicide gene therapy for small cell lung cancer (SCLC). The researchers investigated the use of the yeast cytosine deaminase (YCD) gene alone or fused with the yeast uracil
Cancer
Researchers at the University of Tokyo's Institute of Medical Science have made a significant discovery regarding the role of WD repeat and high-mobility group box DNA binding protein 1 (WDHD1) in lung and esophageal cancer. The study, published in Clinical Cancer Research, aimed to identify novel biomarkers and
Cancer
A team of researchers from Shanghai, People's Republic of China, has made a significant breakthrough in cancer gene therapy using a novel approach that involves targeting tumor cells with nanoscale polymer micelles. According to the study published in Biomaterials, the researchers developed a method to create anti-HIF-1alpha antibody-conjugated
Cancer
Researchers have made a significant discovery in the treatment of melanoma, a type of skin cancer, by identifying key characteristics of promoter regions that define susceptibility to the epigenetic agent decitabine. In a study published in the journal BMC Medical Genomics, J.C. Rubinstein and colleagues from Yale University found
Cancer
Scientists in the United States have successfully engineered gold nanorods with enhanced photothermal stability and gene delivery efficacy using polyelectrolytes. The investigators found that chemically generated gold nanorods rapidly aggregate in biologically relevant media, hindering their effective use in biomedical applications. By depositing polyelectrolyte multilayers on gold nanorods, the researchers
Scientists
Scientists have made new findings in cancer gene therapy, revealing that nitric oxide plays a crucial role in cancer development and progression. Nitric oxide synthase (NOS) is a key enzyme in generating nitric oxide, which is present in both normal and malignant tissues. However, malignant cells express high levels of
Scientists
Scientists at Aarhus University in Denmark have reported the identification of transcripts of negative polarity in simple murine leukemia virus (MLV), a novel mechanism of insertional activation of host genes. This discovery could have significant implications for the design of therapeutic vectors and our understanding of pervasive eukaryotic transcription. The
Cancer
Scientists in the United Kingdom have made a groundbreaking discovery in the field of cancer research, developing a novel CHK1 inhibitor that has the potential to enhance antitumor activity with selected anticancer drugs in vivo. The study, led by M.I. Walton and colleagues at the Institute of Cancer Research,
Cancer
Gene therapy, a relatively new field of medicine, holds promise for treating thoracic malignancies, including mesothelioma and lung cancer, which are associated with a poor prognosis. Current treatment regimens have not been effective in halting the progressive course of these diseases. Researchers at the University of Pennsylvania have been evaluating
Cancer
Gonadotropin hormones, specifically Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH), have been shown to stimulate the migration and proliferation of ovarian cancer cells. Australian researchers, led by I. Mertens-Walker from the University of Sydney, Kolling Institute of Medical Research, conducted an in-depth study on the effects of gonadotropins on ovarian
Cancer
Researchers at Philipps University in Marburg, Germany, have discovered that polyethylenimine (PEI) complexes with small interfering RNA (siRNA) can exert anti-tumor effects synergistically with the monoclonal anti-vascular endothelial growth factor (VEGF) antibody Bevacizumab. The study, published in the Journal of Gene Medicine - Gene Therapy Clinical Trial Database, investigated the
Cancer
Researchers have found new data on germ cell cancer in a recent study published in Pathology, Research and Practice. The study investigated the loss of heterozygosity (LOH) of four tumor suppressor genes in testicular germ cell tumors (TGCTs). The researchers analyzed 38 TGCTs, including 17 seminomas and 21 nonseminomas, and
