Cancer research
Researchers at Fudan University have conducted a study to explore the effects of genetic variation of obesity-related biological pathways and gene-obesity interactions on the incidence of gastric cancer. The study, published in Shanghai yufang yixue, found that obesity-related biological pathway SNP sites and their haplotypes are associated with the risk
Cancer research
Researchers at Fuzhou University in China have made a significant discovery in cancer gene therapy, developing an innovative platform for targeted protein degradation in cancer cells. This breakthrough, published in the Journal of the American Chemical Society, utilises a modular strategy for in situ synthesis of proteolysis-targeting chimeras (PROTACs) through
Genetic research
Researchers from the University of South China have made a significant breakthrough in the detection and treatment of prostate cancer using smart gene circuits. According to a recent study published in Synthetic and Systems Biotechnology, the team has developed artificial gene circuits that can selectively identify prostate cancer cells and
Genetic research
Researchers from Tianjin Medical University have made a significant breakthrough in understanding the absorption, distribution, metabolism, and excretion (ADME) processes that govern drug disposition in the body. According to a study published in Discover Oncology, a novel ADME gene signature has been identified, which serves as a robust prognostic biomarker
Cancer research
Research has been conducted to study the impact of Wilms' tumor 1 gene (WT1) mutation on outcomes of allogeneic hematopoietic-cell transplantation for acute myeloid leukemia (AML). A study published in Bone Marrow Transplantation compared the outcomes of 703 patients with WT1 mutation (mWT1) to those with wild-type WT1 AML
Cancer genetics
Scientists at Fudan University have made significant discoveries in understanding the mechanisms of multiple myeloma, a type of blood cancer. According to a recent study, NR5A2, a transcriptional regulator of lipid metabolism, plays a crucial role in disease progression and drug resistance. The research, published in the International Journal of
Genetic research
Researchers at the Children's Hospital of Soochow University in Suzhou, People's Republic of China, have conducted a study on the clinical features and prognosis of gene mutations in pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL). The study, published in Frontiers in Oncology, analyzed data from
Cancer research
Research conducted at the Third Affiliated Hospital of Sun Yat-Sen University in Guangzhou, People's Republic of China, has demonstrated the safety and efficacy of combining M1-c6v1 oncolytic virus with camrelizumab and apatinib in patients with advanced hepatocellular carcinoma (HCC). The study, which enrolled 13 patients, showed a 70%
Cancer genetics
Researchers from the Netherlands Cancer Institute have developed an inducible CRISPR-Cas9 screening platform that allows for precise temporal control over gene editing in non-proliferative states. This breakthrough has been published in Nature Protocols, offering a detailed protocol for researchers to follow. The platform has the potential to be applied across
Cancer research
Researchers at the University of Texas MD Anderson Cancer Center have made significant strides in understanding the biology of epithelial lineage hierarchies and cancer through the development of a new approach to gene manipulation in esophageal organoids. By utilizing CRISPR-Cas9-based knock-in (KI) methods, scientists can now precisely tag cell lineage
Cancer genetics
A new study from the Second Affiliated Hospital of Soochow University in Suzhou, People's Republic of China, has evaluated the efficacy of PRaG therapy, a combination of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors, radiotherapy, and granulocyte-macrophage colony-stimulating factor, in overcoming resistance
Genetic research
A new study published in the Iranian Biomedical Journal explores the latest advancements in cancer gene therapy, focusing on the use of nanocarriers for delivering drugs to tumors. Researchers from the Iran University of Medical Sciences have identified the benefits of utilizing nanocarriers, including reduced systemic adverse effects, improved bioavailability,
