Cancer research
A new study from the Second Affiliated Hospital of Soochow University in Suzhou, People's Republic of China, has evaluated the efficacy of PRaG therapy, a combination of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors, radiotherapy, and granulocyte-macrophage colony-stimulating factor, in overcoming resistance
Cancer genetics
A recent study conducted by researchers at National University of Misiones, in collaboration with the Florencio Fiorini Foundation, has uncovered a significant connection between type 2 diabetes and cancer. The study aimed to explore the relationship between the PI3K/PTEN/AKT signaling cascade, a crucial pathway in glucose metabolism and
Cancer genetics
Researchers from the Netherlands Cancer Institute have developed an inducible CRISPR-Cas9 screening platform that allows for precise temporal control over gene editing in non-proliferative states. This breakthrough has been published in Nature Protocols, offering a detailed protocol for researchers to follow. The platform has the potential to be applied across
Cancer genetics
A new study from the Second Affiliated Hospital of Soochow University in Suzhou, People's Republic of China, has evaluated the efficacy of PRaG therapy, a combination of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors, radiotherapy, and granulocyte-macrophage colony-stimulating factor, in overcoming resistance
Cancer research
Researchers at the University of Texas MD Anderson Cancer Center have made significant strides in understanding the biology of epithelial lineage hierarchies and cancer through the development of a new approach to gene manipulation in esophageal organoids. By utilizing CRISPR-Cas9-based knock-in (KI) methods, scientists can now precisely tag cell lineage
Cancer genetics
Fresh data on biotechnology and cancer gene therapy have shed light on the regulatory molecule microRNA-17-5p (miR-17-5p), which plays a pivotal role in various diseases, including cancer, inflammatory conditions, and genetic disorders such as cystic fibrosis. Research from the RCSI University of Medicine and Health Sciences has highlighted the potential
Cancer research
Researchers at Lund University, Sweden, have discovered distinct mechanisms of relapse in KMT2A-rearranged acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in infants and children. The study, published in Nature Communications, analyzed whole-genome and exome sequencing of 36 patients with relapsed ALL/AML and found that somatic alterations in
Cancer research
Researchers at Gerash University of Medical Sciences have conducted a systematic review of 26 studies on curcumin's molecular mechanisms and therapeutic potential in treating hepatocellular carcinoma (HCC). The findings suggest that curcumin, a bioactive compound from Curcuma longa, can modulate multiple signaling pathways, leading to enhanced apoptosis, reduced
Cancer research
A recent study published in the European Journal of Pharmaceutical Sciences has shed new light on the development of novel therapy options to address antimicrobial resistance (AMR). Researchers from Philipps-Universität Marburg have investigated the potential of curcumin-loaded liposomes as a treatment for pulmonary infections caused by gram-positive bacteria. The study
Cancer
Research published in Laboratory Investigation presents findings on the heterogeneity of human epidermal growth factor receptor 2 (HER2) in endometrial cancer. The study, conducted at Emory University Hospital, aimed to evaluate HER2 heterogeneity at the protein and gene levels in nonserous endometrial carcinomas. The research revealed significant intratumoral heterogeneity in
Cancer genetics
Research conducted by investigators at Linkou Chang Gung Memorial Hospital has shed new light on the molecular landscape of undifferentiated and dedifferentiated endometrial carcinoma (UDEC), a particularly aggressive subset of endometrial cancer. By employing whole-exome sequencing (WES), the researchers comprehensively characterized the molecular features of 29 UDECs in a single
Cancer research
Men carrying the BRCA1 or BRCA2 gene mutations, like Angelina Jolie, should undergo routine prostate screening from the age of 40, according to the Institute for Cancer Research. This, in turn, could detect prostate cancer earlier, when treatment is more effective. The institute recommends annual NHS checks for this high-risk
