Cancer metastasis

Cancer research

Breakthrough in Prostate Cancer Research: Tgfb1 and Rgd Cooperatively Regulate Smad2/3-mediated Oncogenic Effects

Researchers from the University of Delaware have made a significant breakthrough in understanding the development of prostate cancer, discovering that Tgfb1 and Rgd molecules cooperatively regulate Smad2/3-mediated oncogenic effects in prostate cancer cells grown in bio-orthogonally constructed hydrogels. This study sheds light on the complex mechanisms of tumor progression

Cancer metastasis

Talazoparib and Enzalutamide Combo Shows Improved Survival in Metastatic Prostate Cancer Patients

The combination of talazoparib (Talzenna) and enzalutamide (Xtandi) has been found to improve overall survival (OS) in patients with metastatic castration-resistant prostate cancer (CRPC), according to a press release on findings from the phase 3 TALAPRO-2 trial. The experimental combination significantly improved OS compared to enzalutamide monotherapy in both cohorts