Cancer research
Breast cancer survivors live in constant fear of recurrence, with most relapses and metastatic cancers triggered by sleeper cancer cells that suddenly awake. For a long time, scientists have searched for the triggers that make these cells spring back to life. New research reveals that common respiratory infections, such as
Cancer research
A recent study published in Science China Life Sciences has revealed a crucial role for SAE1, a protein involved in protein SUMOylation, in the progression of non-small cell lung cancer. Researchers found that SAE1 promotes metastasis by stabilizing N-cadherin, a protein involved in the epithelial-mesenchymal transition (EMT), and is highly
Cancer
Investigators at the University of Tabriz have made a significant breakthrough in understanding the role of LncRNA ANRASSF1 in gastric cancer development. According to a recent study, the expression of LncRNA ANRASSF1 is significantly overexpressed in gastric tumors, suggesting its potential as a diagnostic and prognostic biomarker for gastric cancer.
Cancer
Researchers from the Ludwig Institute for Cancer Research have discovered a key mechanism behind the resistance of bone tumors to immunotherapy. By repolarizing neutrophils, a type of frontline immune cell, cancer researchers have found a potential way to improve the efficacy of immunotherapy treatments for bone tumors. The study, led
Cancer
Researchers from Shanghai University have developed a novel metal-free carbon dot nanozyme, known as F-doped CDs (F-CDs) nanozyme, which exhibits a high near-infrared (NIR-II) quantum yield and NIR-I photothermal effect for cancer catalytic immunotherapy. This breakthrough has the potential to revolutionize the treatment of cancer by enhancing the immune response
Cancer
Researchers at the South Dakota School of Mines and Technology have developed a novel nanoparticle-based approach to regulate epithelial-mesenchymal transition (EMT) in cancer cells, potentially inhibiting cancer metastasis. This innovation involves the use of N-cadherin nano-antagonists that induce mesenchymal-epithelial transition (MET) in cancer cells, leading to their inhibited migration, reduced
Cancer research
Yunnan Cancer Hospital has registered a clinical trial to investigate the efficacy of metformin hydrochloride extended release tablets in combination with immune checkpoint inhibitors to treat advanced or metastatic lung squamous cell carcinoma. The study aims to enroll 70 participants with locally advanced or metastatic squamous non-small cell lung cancer
Cancer
As scientists continue to uncover and refine immunotherapies, hope is rising for cancer patients worldwide. The first immunotherapy, approved by the FDA in 2011, ushered in a new era of cancer treatment. Since then, multiple types of immunotherapies have been developed, with some achieving remarkable success in treating various cancers.
Cancer research
Researchers in Singapore have made significant advancements in the diagnosis of metastatic non-small cell lung cancer using a new liquid biopsy technology. The study, conducted by a team from Tan Tock Seng Hospital, evaluated the performance of a circulating tumor DNA (ctDNA) and circulating tumor RNA (ctRNA) liquid biopsy, LiquidHALLMARK
Cancer research
Researchers at the Montefiore Einstein Comprehensive Cancer Center and the University of Colorado Anschutz Medical Campus have made a groundbreaking discovery that respiratory infections, including COVID-19 and influenza, can awaken dormant breast cancer cells that have spread to the lungs, setting the stage for new metastatic tumors. The study, published
Cancer research
Oncolytics Biotech Inc. has initiated regulatory discussions with the U.S. Food and Drug Administration (FDA) for a potential registration-enabled pivotal study in first-line metastatic pancreatic ductal adenocarcinoma (mPDAC). The Company expects to commence study start-up activities before the end of 2025, assuming discussions with the FDA go as expected.
Cancer research
Metastatic hormone refractory prostate cancer (mHRPC) is a life-threatening condition where prostate cancer spreads beyond the gland, often to bones and lymph nodes, posing significant treatment challenges. With symptoms including persistent bone pain, fatigue, weight loss, and urinary issues, patients with mHRPC require systemic therapies to extend survival and enhance
