Cancer research
Advanced-stage prostate cancer, known as metastatic hormone refractory prostate cancer (mHRPC), poses significant treatment challenges. The disease progresses despite anti-androgen treatments, resulting in cancer spreading to bones and lymph nodes. Symptoms include persistent bone pain, fatigue, weight loss, and urinary issues, which can significantly decrease patient quality of life. The
Cancer research
Researchers at Roswell Park Comprehensive Cancer Center have made a significant discovery in understanding the molecular underpinnings of prostate cancer metastasis to the liver. The study, published in the Journal of Clinical Investigation, reveals that serotonin produced by neuroendocrine prostate cancer cells gains access to and activates neutrophils, leading to
Cancer research
Research at the Dr. Josep Trueta University Hospital in Catalonia, Spain, has uncovered a promising combination therapy for non-small cell lung cancer (NSCLC) patients with brain metastases (BM). The study, published in Frontiers in Medicine, demonstrates that silibinin, a flavonolignan with known blood-brain barrier permeability and anti-BM activity, can enhance
Cancer research
A recent study has shed light on the rare case of treatment-related large cell neuroendocrine carcinoma (LCNEPC) of the prostate, highlighting the importance of comprehensive care and multimodal strategies in managing this aggressive subtype of cancer. The case study involved a young patient who developed systemic metastases after undergoing treatment
Cancer research
A promising new approach to combating metastatic triple-negative breast cancer is being explored through a Phase 2 clinical trial currently listed on ClinicalTrials.gov. The trial, led by principal investigator Mary Disis, MD, of the University of Washington, aims to assess the efficacy of a DNA plasmid-based vaccine called STEMVAC
Cancer research
Researchers from the First Affiliated Hospital of Bengbu Medical in Anhui, People's Republic of China, have made a significant discovery in the treatment of brain metastasis from lung cancer. Their study, recently published in Frontiers in Medicine, investigates the radiosensitizing and toxicity-reducing effects of Cycloastragenol (CAG) in radiotherapy
Cancer metastasis
Recent positive topline overall survival (OS) results from the phase 3 EMBARK trial (NCT02319837) have demonstrated that enzalutamide, as a monotherapy and combined with leuprolide, met the key secondary end point with a statistically significant and clinically meaningful improvement in OS vs placebo plus leuprolide in patients with non-metastatic hormone-sensitive
Cancer research
Research published in ESMO Open has demonstrated the long-term effectiveness of nivolumab plus ipilimumab with chemotherapy as a first-line treatment option for patients with metastatic non-small-cell lung cancer (NSCLC). The phase III CheckMate 9LA study, led by Ohio State University, showed that this regimen provided a sustained overall survival (OS)
Cancer research
A new study published in Transplant Immunology has found that the immune checkpoint inhibitor Cemiplimab can be safely used in high immunologic risk kidney transplant recipients with metastatic squamous cell carcinoma. The study, led by researchers at the Cleveland Clinic, reported a case of a patient who received Cemiplimab as
Cancer research
New research from Memorial Sloan-Kettering Cancer Center has made significant findings on genetic evolution in cancer during metastasis, providing new insights into the progression of the disease. According to the study, tumors accumulate copy number alterations (CNAs) to a much greater degree than mutations during distant metastasis. The researchers analyzed
Cancer research
Researchers have made significant strides in understanding the complex genetic underpinnings of lung adenocarcinoma, a leading cause of cancer-related deaths worldwide. A recent study published in the International Journal of Radiation Oncology*Biology*Physics underscores the potential of personalized medicine in treating patients with metastatic lung adenocarcinoma. By analyzing the
Cancer research
Researchers at the Department of Cardiothoracic and Vascular Surgery in Inner Mongolia, People's Republic of China, have reported a case where a 59-year-old female patient with lung adenocarcinoma experienced intestinal obstruction due to small intestine metastasis. The patient's condition deteriorated to intestinal perforation, peritonitis, and infectious
