Cancer research
A recent study published in PLOS Computational Biology has shed new light on the potential biomarkers for pancreatic cancer. The research, conducted by a team of scientists from Lanzhou University, involved an integrated bioinformatics analysis of extensive transcriptome data from 615 pancreatic tumors and 329 adjacent tissues. The study aimed
Cancer genetics
A new study from the Second Affiliated Hospital of Soochow University in Suzhou, People's Republic of China, has evaluated the efficacy of PRaG therapy, a combination of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors, radiotherapy, and granulocyte-macrophage colony-stimulating factor, in overcoming resistance
Cancer research
Researchers from Guangxi Medical University have made a significant discovery in the fight against pancreatic cancer. A novel prodrug molecule, developed to treat pancreatic ductal adenocarcinoma (PDAC), has demonstrated remarkable efficacy in preclinical studies. The prodrug, 4-arm PEG-SS-SN38, harnesses the power of ultrasound to trigger the release of a potent
Bristol-Myers Squibb Co.
Researchers at Bristol-Myers Squibb Company and other institutions have identified complete response/remission (CR) rate as a potential surrogate endpoint in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The study, published in Leukemia Research, analyzed data from 20 randomized controlled trials (RCTs) involving
Cancer
Data from the Medical University of South Carolina show that despite guidelines recommending extended pharmacologic prophylaxis for 30 days after surgery, the adoption of this practice remains low among patients undergoing major cancer surgery. A single-center retrospective cohort study analyzed data from 5246 patients and found that only 17.1%
Cancer cells
A team of researchers at the University of Bonn has made a groundbreaking discovery in the field of ovarian cancer treatment. In a study published in Cell Death Discovery, the researchers investigated the efficacy of PARP inhibitors in treating ovarian cancer cells that are resistant to cisplatin, a commonly used
Cancer research
A comprehensive study published in the journal eClinicalMedicine has highlighted the association between endometriosis and uterine fibroids, with women with endometriosis showing a 2.91 to 10.41 times higher odds of developing fibroids compared to controls. The study, funded by the Italian Ministry of Health, systematically searched PubMed, Embase,
Cancer research
Researchers at the University of Genoa in Italy have made significant contributions to the understanding of PD-L1 expression in gastric cancer. A new report presents findings from a multicentric, real-world retrospective study that analyzed data from 28 Italian pathology centers, covering 1936 cases of esophageal, esophagogastric junction, and gastric carcinoma
Cancer research
A groundbreaking study published in the BMJ Open journal has shed light on the effectiveness of two widely used models in predicting the risk of ovarian malignancy. Researchers from Skane University Hospital and collaborators conducted a systematic review and meta-analysis of external validation studies, comparing the performance of the Risk
Cancer research
According to a recent study published in Frontiers in Oncology, researchers from the Affiliated Tumor Hospital of Xinjiang Medical University have investigated the clinical characteristics, overall survival, and prognostic factors associated with breast cancer patients who have ovarian metastasis. The study analyzed 41 breast cancer patients with pathologically confirmed ovarian
Cancer research
A recent study published in the Journal of Experimental & Clinical Cancer Research has shed light on the mechanisms of immunosuppression in ovarian cancer, a type of cancer that affects women's reproductive organs. Researchers from Shanghai First Maternity and Infant Hospital in China have discovered a novel feedback
Cancer research
Researchers at Lund University, Sweden, have discovered distinct mechanisms of relapse in KMT2A-rearranged acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in infants and children. The study, published in Nature Communications, analyzed whole-genome and exome sequencing of 36 patients with relapsed ALL/AML and found that somatic alterations in
