Cancer research
A recent study published in JAMA compared the use of biparametric (bpMRI) and multiparametric (mpMRI) MRI for prostate cancer diagnosis. The study, led by Prof Freddie Hamdy and Prof Jenny Donovan, found that bpMRI was non-inferior to mpMRI in detecting clinically significant disease. However, the authors emphasized several limitations of
Cancer research
Researchers at the University of Florence, Italy, have made significant advancements in the treatment of gastric cancer using fluorescence-guided surgery. According to the study, published in the journal Biomedicines, the team focused on developing a fluorescent molecule that can selectively target tumor tissues, enabling real-time detection of tumor nodules and
Cancer research
Scientists at Ankara University in Turkey have made significant strides in understanding the complexities of colorectal cancer (CRC) through a comprehensive study that has identified four key genes involved in CRC pathology and development. The groundbreaking research, published in the PeerJ journal, aimed to develop a model for prognosis prediction
Cancer research
Researchers from the University of Gaziantep in Turkey have conducted a comprehensive bioinformatics study to investigate the roles of microRNAs (miRNAs) in colorectal cancer (CRC). The research aimed to identify potential diagnostic biomarkers and therapeutic targets for CRC. Using quantitative real-time PCR (RT-qPCR) and bioinformatic analyses, the study found that
Cancer research
Researchers from the Cell and Matrix Research Institute have published a new study on lung cancer, detailing the development of genetically engineered nanoparticles that demonstrate significant anti-tumor activity. The study, led by Sung-Min Kang, utilized natural killer (NK) cells to create small extracellular vesicles (sEVs) that possess inherent anti-tumor properties.
Cancer research
Researchers from the First Affiliated Hospital of Zhengzhou University in Henan, People's Republic of China, have developed a novel hybrid biomimetic nanoparticle that can target and treat lung cancer and its brain metastases. This "four-in-one" strategy combines phototherapy, gene silencing, immunotherapy, and photothermal effects to trigger
Cancer research
Researchers from NOVA University Lisbon have discovered a promising new strategy in cancer gene therapy using magnetic hyperthermia combined with bioorthogonal chemistry to promote siRNA transfection against the IDO1 gene in dendritic cells. The study, published in Cancer Immunology, Immunotherapy, found that IDO1 silencing decreases around 70% in THP-1-derived dendritic
Cancer research
A new Phase 1 clinical trial, led by Jonsson Comprehensive Cancer Center, aims to assess the effectiveness of a novel imaging technique using flotufolastat F 18, a radioactive imaging agent, in conjunction with positron emission tomography (PET)/computed tomography (CT) scans to guide targeted prostate biopsies in men with prostate
Cancer research
Researchers at the Cancer Institute in Iran have made a significant breakthrough in understanding the relationship between molecular targeted therapy, immunotherapy, and personalized medicine in gastric adenocarcinoma. The study, which was financially supported by Tehran University of Medical Sciences and Health Services, assessed the frequency of microsatellite stable (MSI) status
Cancer research
Scientists from Xi'an Jiaotong University in China have made a groundbreaking discovery in cancer gene therapy, revealing the oncolytic mechanism of Newcastle disease virus (NDV) in a human colonic carcinoma cell line. According to the research, NDV has distinct advantages over other oncolytic viruses, including its safety profile,
Cancer research
A new study published at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC) explores the use of circulating tumor DNA (ctDNA) to personalize consolidation immunotherapy in patients with limited-stage small cell lung cancer (LS-SCLC). The research, led by scientists at the National
Cancer research
A study published in Scientific Reports has found that adjuvant radiotherapy (RT) does not improve long-term survival in elderly male breast cancer patients treated with breast-conserving surgery (BCS). The research, conducted using the Surveillance, Epidemiology, and End Results (SEER) database, included 360 patients with early-stage, low-risk breast cancer (node-negative, hormone
