Cancer research
Researchers from the Petru Poni Institute of Macromolecular Chemistry in Romania have made a significant discovery in the field of cancer gene therapy. They have developed a dual-functional nanoplatform, named carbon dot-enhanced doxorubicin liposomes, which has shown remarkable synergistic antitumor activity. This innovative approach combines the therapeutic effects of doxorubicin,
Cancer research
Researchers from Sichuan University in Chengdu, People's Republic of China, have developed and evaluated a radiomics-based machine learning model to differentiate between lung squamous cell carcinoma (SCC) and adenocarcinoma (AC) in patients with brain metastases (BMs). The study used T1-enhanced magnetic resonance imaging (MRI) features and identified 833
Cancer research
DelveInsight's report, "Recurrent or Metastatic Head and Neck Cancer Pipeline Insight 2025", provides a comprehensive analysis of the pipeline landscape for this devastating disease. As of August 2025, 40+ companies and 40+ pipeline drugs are actively being developed to treat recurrent or metastatic head and neck
Cancer research
A recent study conducted by researchers at Jilin Cancer Hospital in Changchun, China, has shed new light on the effectiveness of targeted therapy combined with immunotherapy in treating patients with late-line metastatic colorectal cancer (mCRC). The study, published in the World Journal of Gastroenterology, compared the outcomes of two common
Cancer research
Scientists at Rizhao People's Hospital in Shandong, People's Republic of China, have made a significant discovery in the field of colon cancer research. Through single-cell RNA sequencing analysis, they identified macrophages as a dominant immune subset that interacts with NK cells and fibroblasts, promoting immunosuppression. This
Cancer research
Trethera Corporation, a clinical stage biopharmaceutical company, has been awarded a $2.3 million Small Business Innovation Research (SBIR) grant from the National Institute of Health (NIH) to develop a novel therapy for metastatic castration-resistant prostate cancer (mCRPC). The grant will fund testing of Trethera's lead drug candidate,
Cancer research
DelveInsight's "Advanced Ovarian Cancer Pipeline Insight 2025" report provides comprehensive insights into the dynamic landscape of 50+ companies and 50+ pipeline drugs in advanced ovarian cancer. The report delves into the clinical and nonclinical stage products, therapeutic assessment by product type, stage, route of administration, and
Cancer research
Research from the University of Sydney has used a novel framework driven by delay integro-differential equations to model the interactions among cancer cells, immune cells, and immune checkpoints in locally advanced microsatellite instability-high (MSI-H) and deficient mismatch repair (dMMR) colorectal cancer (CRC). This approach has enabled the optimisation of neoadjuvant
Cancer research
Recent research from the University of Paris has highlighted the potential of microtubule-targeting agents (MTAs) in treating gliomas and neurodegenerative diseases. MTAs, which disrupt cell division and cell migration, have shown efficacy in tumour suppression and neuronal repair, but their use in the central nervous system (CNS) is hindered by
Cancer research
Researchers at the Chinese Academy of Sciences have made a significant breakthrough in cancer gene therapy with the development of a dendritic cell-liposome conjugate that efficiently reverses immunosuppressive tumor microenvironments, showing remarkable efficiency against colorectal cancer. This innovative approach eliminates tumor-infiltrated Fas MDSCs and enhances TAM phagocytosis in tumors, leading
Cancer research
Research published in Haematologica has shed light on the impact of minimal residual disease (MRD) on the outcome of hematopoietic stem cell transplantation (HSCT) for childhood acute lymphoblastic leukemia (ALL). The study, conducted within the international phase-III FORUM trial, found that MRD positivity was associated with worse event-free survival (EFS)
Cancer research
A recent study published in Biochimica Et Biophysica Acta-molecular Cell Research has shed light on the role of prolyl isomerase Pin4 in the development of ERα-positive breast cancers. Researchers at Hiroshima University found that Pin4 regulates ERα transcriptional activity and is essential for the proliferation of ERα-positive breast cancer cells.
