Cancer research
Pancreatic cancer, one of the most formidable malignancies, has seen minimal improvement in survival rates despite advances in chemotherapy, targeted treatments, and radiation therapy. However, the rapid discovery of the genetic and molecular functions underlying pancreatic cancer has led to new opportunities for targeted therapies, including oncolytic viral therapy. This
Cancer research
Researchers at the University of Kentucky have made new discoveries in cancer gene therapy, specifically focusing on the role of OCT4 in mediating lineage plasticity in prostate cancer. The study, published in the journal Biomedicines, highlights the importance of understanding the molecular mechanisms underlying OCT4-driven plasticity to develop novel therapeutic
Cancer research
Researchers from the First Hospital of China Medical University in Shenyang, People's Republic of China, have made significant progress in understanding and addressing the challenge of cisplatin resistance in laryngeal cancer treatment. By identifying the role of tumor necrosis factor-alpha-induced protein 2 (TNFAIP2) in chemoresistance, the team developed
Cancer research
Scientists have made breakthroughs in using cutting-edge genetic technology to "personalize" cancer treatments. However, Health and Human Services Secretary Robert F. Kennedy, Jr.'s recent funding cuts for mRNA vaccines have sparked alarm among experts, who fear the decision will have a "profound chilling effect"
Cancer research
Current research out of Flinders University has yielded promising results in the treatment of multiple myeloma (MM), an incurable malignancy of plasma cells. According to the study, ferroptosis, a recently characterized form of non-apoptotic programmed cell death, may hold the key to novel treatment strategies. The research demonstrated a strong
Cancer research
I-Mab Biopharma has announced the completion of enrollment in the planned Phase 1b dose expansion cohorts evaluating givastomig, a bispecific Claudin 18.2 x 4-1BB antibody, in combination with nivolumab and mFOLFOX6, for the treatment of gastric cancer. The Phase 1b study, which enrolled 40 patients in the U.S.
Cancer research
A new study has found that incorporating a 70-gene signature (70-GS) into a well-validated breast cancer model, PREDICT, can improve its ability to estimate breast cancer prognosis, potentially reducing overtreatment and its long-term impact on patients' quality of life. The study used data from the MINDACT trial and the
Cancer research
City of Hope's Research Spotlight highlights cutting-edge discoveries in cancer, diabetes, and other life-threatening diseases, offering new hope to patients worldwide. A recent study on a new drug combination has shown potential in slowing the spread of advanced prostate cancer, while a novel AI tool is revolutionizing cancer
Cancer research
Cancer patients struggling with a severe weight loss condition called cachexia may have hope for improved survival and care due to a groundbreaking study that reveals disrupted communication between the brain and liver is the root cause. This condition, which affects one-third of cancer deaths, leads to muscle and fat
Cancer research
Breast cancer survivors live in constant fear of recurrence, with most relapses and metastatic cancers triggered by sleeper cancer cells that suddenly awake. For a long time, scientists have searched for the triggers that make these cells spring back to life. New research reveals that common respiratory infections, such as
Cancer research
A recent study published in Science China Life Sciences has revealed a crucial role for SAE1, a protein involved in protein SUMOylation, in the progression of non-small cell lung cancer. Researchers found that SAE1 promotes metastasis by stabilizing N-cadherin, a protein involved in the epithelial-mesenchymal transition (EMT), and is highly
Cancer research
In a groundbreaking study on mice, researchers have discovered that common respiratory infections, such as COVID, the flu, and other viral infections, can re-awaken dormant breast cancer cells, leading to a surge in cancer activity. This finding has significant implications for breast cancer survivors, as it suggests that protecting themselves
