Cancer research
Researchers at Queen Mary University of London and the London School of Hygiene and Tropical Medicine have conducted an analysis that suggests more women at higher risk of breast cancer should be offered a mastectomy. According to the study published in JAMA Oncology, mastectomy is a cost-effective way to reduce
Cancer research
Gallbladder cancer patients undergoing resection between 2002 and 2021 were studied to determine the prognostic significance of baseline serum carbohydrate antigen (CA) 19-9 and carcinoembryonic antigen (CEA) levels. Researchers from Ohio State University found that individuals with low CA19-9/low CEA levels had the most favorable 3-year recurrence-free survival (RFS)
Cancer research
Investigators at Thompson Rivers University have published a new report on Cancer, highlighting the importance of integrating gene expression and DNA methylation data to improve tumor classification accuracy and detect misclassified tumors. The research, supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), utilized 6216 samples from
Cancer research
Researchers at Chongqing Medical University in Chongqing, People's Republic of China, have made a significant discovery in the field of cancer research, unveiling the crucial role of urea transporters (UTs) in human diseases. The study, published in Sub-cellular Biochemistry, reveals that UT-B and UT-A, encoded by Slc14A1 and
Cancer research
Investigators at the National Cancer Center in South Korea have published a new study on the clinical significance of circulating tumor DNA (ctDNA) KRAS mutations in patients with pancreatic adenocarcinoma (PAC). The research aimed to propose a cut-off value of mutant KRAS (mKRAS) concentration in ctDNA and validate its clinical
Cancer research
Researchers at Roswell Park Comprehensive Cancer Center have made a significant discovery in understanding the molecular underpinnings of prostate cancer metastasis to the liver. The study, published in the Journal of Clinical Investigation, reveals that serotonin produced by neuroendocrine prostate cancer cells gains access to and activates neutrophils, leading to
Cancer research
New research at the University of Nebraska Medical Center has found that glycosylation, specifically tumor cell sialylation, regulates immune evasion and metastasis in non-small cell lung cancer. The study, funded by various organizations including the National Institutes of Health, identified a key role for the ST6GalNAc-I enzyme in sialylation of
Cancer research
Researchers at Leiden University Medical Center have made a significant breakthrough in the study of colon cancer, discovering that tumor desialylation can surpass anti-PD-L1 checkpoint therapy in restoring anti-tumor immunity in a murine model for colorectal cancer. The study, published in the International Journal of Cancer, found that ablation of
Cancer research
Researchers from Wroclaw Medical University in Poland have presented data on the increasing incidence of genitourinary cancers, including prostate cancer, kidney cancer, bladder cancer, and testicular cancer. The team has highlighted the importance of tumor markers in the diagnosis and treatment of these diseases. According to the research, tumor markers
Cancer research
Investigators at Camden, New Jersey's Cooper University Hospital have called for research into the outcomes of genetic counseling for individuals at risk of hereditary cancer. The National Society of Genetic Counselors (NSGC) plans to develop an evidence-based guideline on these outcomes, but evidence gaps in the literature have
Cancer research
A recent study has shed new light on the effect of radiotherapy on prostate cancer patients, particularly in regards to dose-response mapping (DRM) and its impact on identifying high-risk subregions in the bladder and rectum. Key Takeaways: * The study analyzed 1808 datasets from prostate cancer patients undergoing radiotherapy, with 589
Cancer research
Chris O'Brien Lifehouse has launched the ACTIDIET-PRO study, a clinical trial to assess the effects of a lifestyle intervention on physical activity and diet in patients with metastatic prostate cancer receiving novel hormonal agents. The study aims to evaluate the feasibility of an exercise and diet intervention in
