Cancer research
Research at the Dr. Josep Trueta University Hospital in Catalonia, Spain, has uncovered a promising combination therapy for non-small cell lung cancer (NSCLC) patients with brain metastases (BM). The study, published in Frontiers in Medicine, demonstrates that silibinin, a flavonolignan with known blood-brain barrier permeability and anti-BM activity, can enhance
Cancer research
A promising new approach to combating metastatic triple-negative breast cancer is being explored through a Phase 2 clinical trial currently listed on ClinicalTrials.gov. The trial, led by principal investigator Mary Disis, MD, of the University of Washington, aims to assess the efficacy of a DNA plasmid-based vaccine called STEMVAC
Cancer research
A team of researchers from the Faculty of Sciences, Ibnou Zohr University, Agadir, Morocco, has discovered a novel hybrid 1,2,3-triazole-thiosemicarbazone compound with a strong binding affinity with ESR1, a key target for breast cancer treatment. The compound, synthesized through a multi-step process, exhibits notable stability and interactability with
Cancer research
Researchers at the Mayo Clinic have investigated the effect of salvage radiation therapy (SRT) on the long-term natural history of biochemical recurrence (BCR) in patients with prostate cancer after radical prostatectomy. The study examined the outcomes of 6881 patients with BCR, with 2109 receiving SRT and 4772 undergoing observation alone.
Cancer research
Researchers at the University of Tehran have made significant breakthroughs in cancer gene therapy, specifically focusing on the combination of PTEN and p53 genes to target and kill cancer cells. This promising approach has shown remarkable antitumor effects in colorectal cancer cells, demonstrating a synergistic impact when combined. The study
Cancer research
Research conducted by the Agency for Science Technology and Research (A*STAR) in Singapore has led to a novel approach in cancer treatment, using the PRL3-zumab to target intracellular oncoproteins. The study, published in Cell Reports Medicine, demonstrated the efficacy of PRL3-zumab in prolonging progression-free survival in patients with late-stage
Cancer research
A new study conducted by the Global Robotics Institute has shed light on the varying outcomes of ductal adenocarcinoma (DAC) and acinar adenocarcinoma (AAC) in patients undergoing robotic-assisted radical prostatectomy (RARP). The research, published in the International Urology and Nephrology journal, found that DAC was associated with higher extracapsular extension
Cancer research
Researchers from the First Affiliated Hospital of Bengbu Medical in Anhui, People's Republic of China, have made a significant discovery in the treatment of brain metastasis from lung cancer. Their study, recently published in Frontiers in Medicine, investigates the radiosensitizing and toxicity-reducing effects of Cycloastragenol (CAG) in radiotherapy
Cancer research
A recent study published in the Journal of Lipid Research has made new findings in colitis, a type of inflammatory bowel disease. The research, conducted at Cardiff University, has revealed that helminth-induced prostaglandin signaling and dietary shifts in polyunsaturated fatty acid (PUFA) metabolism can promote colitis-associated cancer. Key Takeaways: * The
Cancer research
Research by Dr Seyed Mehdi Jafarnejad at Queen's University Belfast has been awarded £314,945 by Breast Cancer Now to investigate the role of the ZFP36L1 protein in breast cancer risk. The study aims to understand why lower levels of this protein increase the risk of breast cancer,
Cancer research
Researchers at Adana Alparslan Turkes Science and Technology University have made a significant breakthrough in using machine learning models to predict the response of rectal cancer patients to neoadjuvant chemoradiotherapy (nCRT). The study, published in Medicine, aimed to compare the performance of various machine learning models in predicting the response
Cancer research
Researchers at the School of Nursing in Amman, Jordan, have conducted a systematic review to evaluate the application of artificial intelligence and machine learning techniques in predicting neuropathic pain in patients with cancer. The study, published in the Digital Health journal, highlights the potential of AI and ML in enhancing
