Cancer
Research from Zhengzhou University has led to the development of an ultrasound-visualized methionine partitioning nano-modulator that aims to improve the efficacy of tumor immunotherapy. This innovative approach involves reducing methionine uptake by tumor cells, suppressing tumor glycolysis, and alleviating the acidic tumor microenvironment. By leveraging ultrasound guidance and liquid-gas phase
Cancer research
Researchers at Weill Cornell Medicine have made a significant breakthrough in cancer immunotherapy, discovering a potent small molecule inhibitor of the lymphocyte activation gene-3 (LAG-3) protein. The novel compound, identified through a DNA-encoded chemical library (DEL) screen, exhibits submicromolar affinity for LAG-3 and disrupts the LAG-3/MHCII interaction, which plays
Cancer research
Researchers from the Department of Cardiology, Jilin Province FAW General Hospital, have made significant progress in developing nanocarrier-based delivery systems for treating bone cancer. According to a recent study published in IUBMB Life, these systems have improved the bioavailability and targeting of tyrosine kinase inhibitors (TKIs) in bone cancer therapy,
Cancer research
Jonsson Comprehensive Cancer Center has launched a Phase 2 interventional clinical trial, ANDROMEDA, aimed at studying the combination of alpha-emitting or beta-emitting radionuclides with metastasis-directed stereotactic body radiotherapy for oligorecurrent prostate adenocarcinoma. The trial is led by principal investigator Amar Kishan and involves 107 participants from the USA. Although the
Cancer research
Researchers at Xinjiang University have made a groundbreaking discovery in the field of cancer gene therapy, revealing that oncolytic herpes simplex virus type 1 (HSV-1) engineered with interleukin-12 (IL-12) and interleukin-15 (IL-15) genes can significantly enhance antitumor immunity. The study, published in Molecular Therapy Oncology, demonstrated the impressive antitumor efficacy
Cancer research
A team of researchers at Merck & Company in Rahway, New Jersey, has published a new study on cancer therapy, revealing key insights into the properties of vibostolimab, a humanized anti-T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) antibody. The study, titled "Pharmacological and structural characterization of vibostolimab,
Cancer
Researchers from the University of Tokyo have discovered a breakthrough in cancer gene therapy using silica-coated polyion complexes (SPICs) to enhance pulmonary mRNA delivery. This innovative approach balances particle stability for payload protection and release, holding great promise for the treatment of lung diseases. The study highlights the importance of
Cancer
The DKMS Stiftung Leben Spenden has been supporting young international scientists with a doctoral degree in medicine or natural sciences since 2015 through the DKMS John Hansen Research Grant. The grant focuses on innovative research projects in transplant immunology, new approaches to treat complications following stem cell transplantation, donor selection,
Cancer research
Researchers from the University of Cologne have made a significant breakthrough in the field of cancer gene therapy. A new tool, the FluoroDetect assay, has been developed to assess the functionality of nucleic acid-based therapeutics, such as small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs). This innovative assay uses a
Cancer research
Researchers at the University of Utah have made a significant breakthrough in developing a novel gene therapy for treating hepatocellular carcinoma (HCC), a type of liver cancer. The therapy, called mitochondrially targeted p53-Bad* fusion gene therapy, has shown promising results in promoting apoptosis in HCC cells by inhibiting the Bcl-2
Cancer
Researchers from Technological University Dublin have developed a new gene delivery vector, known as Hyperbranched poly(b-amino ester)s (HPAEs), which has shown superior functionalization potential and improved transfection efficacy in glioma cells. The vector, modified with tryptamine, has demonstrated enhanced transfection efficacy by 2-3-fold compared to unmodified HPAEs, while
Cancer research
Fresh data on pancreatic cancer have shed new light on the mechanisms driving cancer resistance to immunotherapy. A recent study published in Frontiers in Immunology has found that tumor-intrinsic interferon (IFN) signaling may contribute to pancreatic cancer cells' ability to evade treatment. Researchers at the University of North Carolina
