Cancer
Researchers at the College of Pharmacy have successfully designed a near-infrared light-induced transformative nanoparticle platform that combines photothermal ablation with immunotherapy to effectively treat cancer. The innovative approach, known as photothermal immunotherapy, has shown promising results in treating both primary and distant tumors in a mouse breast cancer model. The
Cancer
Investigators at Leidos Biomedical Research, Inc. have discovered that two proteins, Fnip1 and Fnip2, play crucial roles in kidney tumor suppression in cooperation with Folliculin, a tumor suppressor for kidney cancer. The research, published in the Proceedings of the National Academy of Sciences, highlights the importance of these proteins in
Cancer
A breakthrough in cancer treatment has been patented, utilizing a fusion protein that targets angiogenesis, a crucial process in cancer growth. The patent, filed on July 25, 2012, and published on March 24, 2015, is assigned to Samsung Electronics Co., Ltd. and details a novel approach to treating cancer using
Cancer
A new approach to combat the growing global burden of cancer is being explored by researchers, leveraging the human genome project to develop molecular-targeted treatments. The world is facing an increasing number of new cancer cases, predominantly in developing countries, which demands a more comprehensive and integrated approach to cancer
Cancer
New research published in the International Journal of Molecular Sciences has shed light on the relationship between genotoxic cancer drugs and checkpoint adaptation, a process that can lead to genomic instability in cancer cells. According to the study, when human cells detect damaged DNA, they initiate a DNA damage response
Cancer
Researchers at Tri-Service General Hospital in Taipei, Taiwan, have investigated the therapeutic effect of an anti-cancer protein, decorin, delivered via an adeno-associated viral (AAV2) gene delivery system in a xenograft U87MG glioma tumor in the brain of nude mice. The study found that decorin expression from the AAV vector inhibited
Cancer research
Researchers from the University of British Columbia have discovered that Y-box binding protein-1 (YB-1) plays a crucial role in the development of breast cancer. YB-1 is an oncogenic transcription/translation factor expressed in 40% of breast cancers, where it is associated with poor prognosis, disease recurrence, and drug resistance. The
Cancer
Cancer has emerged as the deadliest disease in the world, and researchers are racing to understand its complex mechanisms. Recent studies on sphingolipids have shed light on their role in controlling various aspects of cell growth and proliferation in cancer. Sphingolipids, including ceramide and sphingosine-1-phosphate, have been implicated in the
Cancer
MabVax Therapeutics, a clinical stage biotechnology company, has received the Phase 2 portion of the Small Business Innovation Research Grant (SBIR) from the National Cancer Institute (NCI) for the development of its sarcoma vaccine. The grant, valued at $1,752,000 over three years, will support the Phase II clinical
Cancer research
Recent research from Atlanta highlights the crucial role of nucleic acids (DNA and RNA) in cells and the urgent need for novel therapeutic agents to treat various deadly cancers and drug-resistant pathogens. Despite the importance of targeting nucleic acids, the lack of 3D structural information has hindered drug discovery. However,
Cancer research
A recent study published in the International Journal of Biological Macromolecules investigates the interaction between the anticancer drug mitoxantrone and chromatin proteins, core histones, and H1 in solution. The research team, led by Z. Hajihassan from the University of Tehran, Institute of Biochemistry and Biophysics, used fluorescence, UV/Vis, CD
Cancer research
Scientists from the Indian Institute of Technology have made groundbreaking findings in the treatment of breast cancer, as published in the Journal of Cellular Physiology. Their research reveals that combining ZD6474, a dual tyrosine kinase inhibitor, with paclitaxel can significantly enhance the medication's antiproliferative and apoptotic effects in
