Cancer treatment

Cancer treatment

Loss of Kelch-like ECH-associated protein 1 Function in Prostate Cancer Cells Contributes to Chemoresistance and Radioresistance

Prostate cancer cells with defective Kelch-like ECH-associated protein 1 (Keap1) function exhibit increased resistance to chemotherapy and radiation, enabling tumor growth and proliferation. Research led by P. Zhang and colleagues at the Johns Hopkins University's Sidney Kimmel Comprehensive Cancer Center has shed light on the mechanisms underlying this

Drugs

Bexarotene Shows Promise in Chemoprevention of Small Cell Lung Cancer

New research has shed light on the potential of bexarotene, a retinoid X receptor agonist, in the prevention of small cell lung cancer. A study conducted by researchers at the Washington University, Alvin J. Siteman Cancer Center, has revealed that bexarotene significantly reduced tumor incidence, number, and load in a

Cancer research

Reconstitution of Amphiregulin-EGF Receptor Signaling Contributes to Cancer-Associated Bone Pathology

Researchers at Indiana University have made a significant discovery about the mechanism by which epidermal growth factor receptor (EGFR) signaling contributes to cancer-associated bone pathology. According to a study published in Molecular Cancer Research, the researchers found that amphiregulin (AREG) stimulation of EGFR results in high levels of parathyroid hormone-related

Cancer research

Tobacco-Specific Carcinogen NNK Linked to DNA Hypermethylation and Poor Prognosis in Lung Cancer Patients

A study published in The Journal of Clinical Investigation has revealed a mechanism by which the tobacco-specific carcinogen NNK induces DNA methyltransferase 1 (DNMT1) accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. The research, conducted by R.K. Lin and colleagues at National Cheng Kung University

Drugs

Luteolin Inhibits Prostate Cancer Cells through Epigenetic Control of Key Genes

A recent study published in the Journal of Steroid Biochemistry and Molecular Biology has identified the regulation of cell cycle and RNA transcription genes in PC-3 human prostate cancer cells treated with luteolin. The research reveals that luteolin significantly inhibits prostate cancer cells in vitro and in vivo, but the

Cancer treatment

Evolving Role of Monoclonal Antibodies in Colorectal Cancer Treatment

Researchers in the United States, led by C. Eng of the University of Texas M.D. Anderson Cancer Center, have published a new report on the evolving role of monoclonal antibodies in treating colorectal cancer. The study highlights the critical impact of molecular markers on the effectiveness of targeted biologic

Cancer treatment

Novel Cdk Inhibitor Xylocydine Shown to be Effective in Inducing Apoptosis in Hepatocellular Carcinoma Cells

Researchers in Seoul, Korea have discovered that a novel Cdk inhibitor, xylocydine, is an effective inducer of apoptosis in hepatocellular carcinoma (HCC) cells in vitro and in vivo. The study, published in Cancer Letters, demonstrates that xylocydine selectively down-regulates the activity of Cdk1 and Cdk2, leading to significant cell growth

Cancer research

Breakthrough in Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Research

A team of researchers at the University of South Carolina's Hollings Cancer Center has made significant progress in understanding the treatment of precursor T-cell lymphoblastic leukemia-lymphoma (pre-T-LBL/T-ALL), a type of blood cancer. According to their study published in the journal Blood, the team has identified a small

Drugs

Arsenic Trioxide and Epigenetic Therapeutic Agents Show Promise in Leukemia Research

A recent report from researchers in Shantou, People's Republic of China, has shed new light on the potential growth-inhibiting effects of arsenic trioxide when combined with epigenetic therapeutic agents on leukemia cell lines. The study, published in Leukemia & Lymphoma, found that arsenic trioxide down-regulated the global DNA

Cancer research

Theaflavins Induce Apoptosis in Breast Cancer Cells through Multiple Pathways

Recent research published in the journal Carcinogenesis has revealed that theaflavins, a type of polyphenol found in tea, can induce apoptosis in p53-mutated human breast cancer cells. The study found that theaflavins target two distinct signaling pathways, Fas/caspase-8 and Akt/pBad, to induce mitochondrial death cascade and ultimately lead

Drugs

Novel Strategy to Inhibit Pancreatic Cancer Growth

Deregulation of insulin-like growth factor-1 receptor (IGF-1R) and focal adhesion kinase (FAK) signaling pathways plays a significant role in cancer cell proliferation and metastasis. Researchers have found that a new strategy to inhibit both FAK and IGF-1R signaling pathways is effective in decreasing the growth of pancreatic cancer xenografts. This

Cancer treatment

Telomere Maintenance Crucial in Overcoming Cancer Drug Resistance

Researchers at Wayne State University have made significant discoveries about the role of telomeres and telomerase in cancer drug resistance. Their study, published in the Journal of Chemotherapy, found that changes in telomerase activity and/or telomere length are key factors in the development of resistance to cancer drugs. The