Cancer research
A study from Sydney, Australia, reveals that p21(WAF1) can induce cell-cycle arrest but also promote tumor growth by repressing gene transcription of thioredoxin-binding protein 2 (TBP2) in cancer cells. This paradox has been attributed to the complex role of p21(WAF1) in cancer therapy, where it can act as
Cancer research
Scientists in Guangzhou, People's Republic of China, have developed a promising non-viral gene therapy approach for cervical cancer, targeting the survivin gene. The researchers constructed a recombinant expression plasmid of short hairpin RNA (shRNA) that specifically down-regulates the expression of the survivin gene. When added to cultured cervical
Cancer research
Researchers have found that the NRG1 gene is frequently silenced by methylation in breast cancers, and is a strong candidate for the 8p tumour suppressor gene. The study, published in the journal Oncogene, found that most breast cancer cell lines had reduced or undetectable expression of NRG1, and that expression
Drugs
Researchers at Uppsala University in Sweden have been investigating the potential of CD40 ligand (CD40L) gene therapy in treating aggressive bladder cancer. Their study, published in the Journal of Immunotherapy, involved using adenoviral vectors to deliver the CD40L gene into the bladder of mice with disseminated cancer. The results showed
Drugs
Scientists in the United States have reported the development of a novel cationic polymer, EGDE-3,3', that significantly enhances adenoviral gene therapy for cancer. The polymer was found to increase infectivity and transgene expression, with a 100-fold reduction in the amount of adenovirus required to transduce 50-60% of cancer
Cancer research
Recent research in the United Kingdom has shed light on a critical pathway in metastatic melanoma, the most deadly form of skin cancer, which claims a 5-year survival rate of less than 15%. Study findings indicate that Nuclear Factor of Activated T-cells (NFAT) plays a pivotal role in the progression
Cancer research
A groundbreaking study from Shanghai, China, presents a promising new strategy for treating cancer. Immunotoxin therapy has shown potential in targeting tumor cells while minimizing harm to healthy tissues. However, its clinical application has been limited by its short half-life and rapid clearance. Researchers from Shanghai Jiaotong University have developed
Cancer
Researchers in Greece have developed a replication-defective recombinant adenovirus (RAd) vector expressing human CD40 ligand (RAd-hCD40L) which shows direct anti-proliferative and pro-apoptotic effects on malignant cells. The study, published in Cancer Gene Therapy, found that transduction of CD40-positive bladder, cervical, and ovarian carcinoma cell lines with RAd-hCD40L potently inhibits their
Cancer
Researchers in the United States have found that the loss of p21(WAF1) promotes adenovirus replication and more effective cell killing, offering potential therapeutic benefits for cancer treatment. A study published in Cancer Gene Therapy reveals that knocking down p21(WAF1) in cancer cells enhances the replication and killing of
Drugs
Researchers in Larisa, Greece, conducted a meta-analysis to investigate the relationship between MTHFR gene polymorphisms and response to fluorouracil-based chemotherapy in patients with colorectal cancer. The analysis included ten studies relating MTHFR C677T and six studies relating MTHFR A1298C to the response to chemotherapy. The study found that for both
Drugs
Researchers in the United States have made a groundbreaking discovery in the fight against metastatic prostate cancer. A new study published in the journal Oncogene has found that a novel proteasome inhibitor, NPI-0052, has the potential to inhibit the spread of cancer cells by targeting a key protein involved in
Drugs
Researchers at the University of Heidelberg in Germany have made a significant discovery about the epigenetic regulation of genes in gliomas, a type of brain cancer. The study found that the death receptor 4 (DR4) gene is frequently methylated in human astrocytic gliomas, leading to resistance to tumor necrosis factor-related
