Cancer research
Scientists from Hokkaido University have published a study on the synergistic effects of Trichostatin A (TSA) in combination with p53 gene transfer on inducing apoptosis in breast cancer cells, specifically the MDA-MB-231 cell line. The researchers found that while p53 gene transfer alone induced apoptosis at a low level, the
Cancer research
Recent research from Central South University in Hunan, People's Republic of China, has shed light on the potential of DNAzyme targeting matrix metalloproteinase-9 (MMP-9) in inhibiting cancer cell proliferation, migration, and invasion. Scientists discovered that DNAzyme targeting MMP-9 strongly inhibited MMP-9 mRNA and protein expression in non-small cell
Cancer
A new report from researchers at Nanjing University in China has made significant findings in the development of a novel cancer treatment. The study used the probiotic Bifidobacterium longum as a delivery system for the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and endostatin, which when combined with low-dose chemotherapeutic drugs,
Cancer research
Scientists in the United States have made a significant discovery in the treatment of prostate cancer, specifically in cases where the disease has metastasized to bone. Dasatinib, a small molecule kinase inhibitor, was found to inhibit the growth of prostate cancer in bone and provide additional protection from osteolysis. The
Cancer research
Recent research from Duke University has shed light on the crucial role of MLH1 expression in sensitizing ovarian cancer cells to cell death mediated by XIAP inhibition. The study investigated the correlation between MLH1 expression and clinical response to platinum drugs in advanced-stage epithelial ovarian cancer (EOC) patients. The results
Cancer
Recent research from Wake Forest University's Medical Department has provided significant insights into the molecular events underlying cell death triggered by the cancer chemotherapeutic drug cisplatin. The study discovered that mismatch repair (MMR) proteins participate in cytotoxicity induced by cisplatin, a key finding that can improve our understanding
Cancer
A nonviral gene delivery system using a composite of piggyBac (PB) transposon and polyethylenimine (PEI) was developed to support stable genomic integration and persistent gene expression in vivo. In a study published in BMC Cancer, researchers from Fudan University successfully applied this system to treat ovarian cancer in mice. The
Cancer
Researchers in Caen, France, have found that the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) has limited effectiveness in treating malignant glioma, a type of brain cancer. The study, published in Clinical Cancer Research, used a panel of six human malignant gliomas with different molecular alterations
Cancer
Scientists in Luxembourg have made a significant breakthrough in cancer research by investigating the potential of naturally occurring organic sulfur compounds (OSCs) in treating leukemia. Their study, published in Apoptosis, has identified a compound, diallyltetrasulfide (Al2S4), which has shown promise in inducing apoptosis in cancer cells. The researchers found that
Cancer research
Scientists in Sapporo, Japan have developed a novel gene transfer therapy that combines the activation of the p53 protein with the suppression of the tumor-suppressive protein p21. This approach aims to enhance the effectiveness of cancer therapy by preferentially inducing apoptosis in cancer cells. The researchers constructed an adenovirus vector
Cancer research
Researchers at the University of Washington have developed a stem cell gene therapy approach that shows promise in delaying tumor growth in a mouse model of breast cancer. The therapy involves genetic modification of hematopoietic stem cells (HSCs) to express a relaxin (Rlx) gene, which degrades tumor stroma and allows
Drugs
Researchers have identified DNA licensing as a new androgen receptor (AR) mediated therapeutic target for prostate cancer. According to a study published in Endocrine-related Cancer, during the cell cycle, the androgen receptor plays a crucial role in regulating DNA replication and cell proliferation. In normal prostate cells, the androgen receptor
