Drugs
Hyperthermia, or heat therapy, has been shown to induce apoptosis in cancer cells, particularly in breast cancer cells. Recent research published in the Journal of Cellular Biochemistry has investigated the regulatory mechanisms of hyperthermia-induced apoptosis in MCF-7 breast cancer cells. The study found that hyperthermia exposure at 43°C increases
Cancer research
Scientists in Suita, Japan have made significant progress in the field of cancer gene therapy with the discovery of a systemic NK4 gene therapy that inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models. This breakthrough finding has the potential to revolutionize the treatment
Cancer research
Researchers in Bologna, Italy have developed a second-generation DNA-based vaccine, known as Tri-DNA, that shows promise in preventing cancer. The vaccine is made up of three gene components: a transmembrane-extracellular domain fragment of the Neu gene, interleukin (IL)-12 genes, and the H-2D(q) allogeneic MHC gene. In a study
Cancer research
A recent study conducted by researchers in Shanghai, People's Republic of China, has evaluated the efficacy and tolerability of combination chemotherapy with epirubicin, cisplatin, 5-fluorouracil, and Chloroxoquinoline in patients with metastatic gastric cancer. The study involved 22 patients who received a combination of epirubicin, cisplatin, 5-fluorouracil, and Chloroxoquinoline,
Cancer
Recent years have seen a significant increase in the development of protein kinase inhibitors as a therapeutic approach for various diseases, including cancer. However, the challenge of modulating protein kinase activities safely and effectively for the treatment of chronic diseases remains unresolved. Researchers have identified several protein kinases, including p38
Cancer research
A landmark article published in the June 16, 2009 issue of Molecular Therapy, the Official Journal of The American Society of Gene Therapy, sheds light on the remarkable efficacy of Epeius Biotechnologies' lead product, Rexin-G, in treating metastatic cancer. The tumor-targeted anti-cancer agent, designed to spare normal cells and
Cancer
Recent studies have identified unique microRNAs (miRNAs) in colonic tumor tissue and blood that may accurately diagnose the presence of colorectal cancer and help predict disease recurrence. Researchers from the University of Leicester, UK have explored the potential role of these biomarkers in the diagnosis, progression, and recurrence of colorectal
Cancer
A new report from researchers at Roswell Park Cancer Institute reveals that the secretion of stress protein grp170 promotes immune-mediated inhibition of murine prostate tumor cells. The study demonstrates that genetic modification of weakly immunogenic murine prostate tumor cells (TRAMP-C2) by stable transfection with a secretable form of endoplasmic reticulum
Cancer research
Recent research published in Cancer Gene Therapy has shed light on the mechanisms of adenoviral-mediated interferon alpha (Ad-IFN) in killing cancer cells. The study, led by M.B. Fisher and colleagues from the University of Texas, M.D. Anderson Cancer Center, demonstrates that Ad-IFN produces cancer-specific cell death through direct
Cancer research
Research published in the journal Gene Therapy has presented a promising approach to treating malignant melanoma using a genetically engineered Newcastle disease virus (NDV). The study, conducted by D. Zamarin and colleagues at the Mount Sinai School of Medicine, demonstrates the potential of NDV as an effective agent for therapy
Cancer
Cancer gene therapy researchers in Guildford, the United Kingdom, have discovered that inhibiting aquaporin 3 increases the sensitivity of prostate cancer cells to cryotherapy. This breakthrough study findings suggest that targeting aquaporin 3 may improve the efficacy of prostate cryotherapy. The researchers used PC-3 and DU145 prostate cancer cells and
Cancer
The Forsyth Regional Cancer Center at Forsyth Medical Center in Winston-Salem, NC is participating in a national trial of the experimental drug Avastin to treat glioblastoma, a fast-growing tumor of the brain or spinal cord. This phase of the trial, testing the effectiveness of Avastin in conjunction with standard chemotherapy
