Cancer research
Researchers in China have discovered new data on cancer gene therapy involving a tumor suppressor gene PIG11. The study found that PIG11 expression was significantly downregulated in human hepatocellular carcinoma (HCC) tissue and cell lines. Furthermore, the study revealed that HepG2 cells were more sensitive to arsenic trioxide (As2O3)-induced
Cancer research
Researchers at the University of Texas M.D. Anderson Cancer Center have discovered a new function of the protein Artemis, which acts as a negative regulator of p53 in response to oxidative stress. This discovery sheds light on the complex interactions between Artemis, DNA-PKcs, and p53, and has significant implications
Cancer
Researchers at Hokkaido University's Medical Department conducted a study to investigate the efficacy of combination therapy in treating pancreatic ductal adenocarcinoma (PDAC). The study involved the use of adenovirus vectors to deliver the 4E-BP1 gene, which is a translation repressor, in combination with the mTOR inhibitor rapamycin. The
Pharmaceutical industry
Pfizer and Celldex Therapeutics presented updated data from two clinical trials of CDX-110 in newly-diagnosed glioblastoma multiforme (GBM) patients at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO). The trials, ACTIVATE and ACT II, showed that CDX-110 may improve time to tumor recurrence and overall survival
Pharmaceutical industry
Advanced non-small cell lung cancer (NSCLC) is a devastating disease with a poor prognosis, with only 10% of patients alive five years after diagnosis. A randomized Phase IIb study of the investigational therapeutic cancer vaccine Stimuvax (BLP25 liposome vaccine) has shown promising results in patients with inoperable advanced (stage IIIb/
Cancer research
Breast cancer is a complex and aggressive disease that can metastasize to various organs in the body, making it challenging to treat. Recent research has shed new light on the role of chemokine receptors in the development and progression of breast cancer, particularly in metastatic disease sites. A study published
Cancer
Recent research has identified a synthetic tylophorine derivative, PBT-1, as a potential anticancer agent. Investigators at National Taiwan University found that PBT-1 significantly inhibits growth of various cancer cells, including lung cancer, by inducing cell cycle G2/M arrest and apoptosis. The study published in the Journal of Medicinal Chemistry
Cancer research
Recent research from the University of Tokyo has presented fresh data on a novel cancer gene therapy approach that utilizes the proapoptotic molecule Noxa to selectively eliminate tumor cells. The study's findings suggest that inducing apoptosis in cancer cells without affecting normal cells is a critical issue in
Cancer
Scientists in Hangzhou, People's Republic of China, have made a groundbreaking discovery in the field of cancer gene therapy. They have developed a highly effective treatment for colorectal cancer by inserting the suppression of tumorigenicity 13 (ST13) gene into a double-regulated oncolytic adenovirus, known as SG500. This innovative
Cancer research
A recent study published in the journal Proceedings of the National Academy of Sciences of the United States of America has demonstrated the efficacy of engineered mesenchymal stem cells (MSCs) in delivering therapeutic agents to glioblastoma, a highly malignant and invasive form of brain cancer. The researchers, led by L.
Cancer
Recent research from the University States suggests that topical application of vitamin E may help prevent skin cancer in humans. A study published in Cancer Prevention Research found that healthy human volunteers who applied a cream containing 12.5% vitamin E to their skin showed a significant reduction in the
Cancer research
Researchers have published the results of a study on the combination of immunotherapy with radiation and CpG-based tumor vaccination to eradicate radio- and immuno-resistant lung carcinoma cells. The study found that this approach holds promise in treating intractable carcinoma. The researchers used a combination of radiation and CpG-based tumor vaccination
