Cancer
Researchers at the University of Kuopio in Finland have discovered that combining antiangiogenic gene therapy may be a potential approach for treating ovarian cancer. The study, published in Molecular Therapy, involved the use of soluble forms of vascular endothelial growth factor receptors (VEGFRs) to inhibit the growth of tumors in
Cancer
Scientists in Sendai, Japan, have discovered a new potential therapeutic strategy for cancer treatment by investigating the effects of serotonin on tumor growth. The researchers used 5-HT transporter knockout (5-HTT(-/-)) mice, which showed a decreased level of serotonin, and found that tumor growth was significantly attenuated in these
Cancer
Researchers in Kumamoto, Japan, have discovered that the prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk of cancer, and they suspect that this anti-tumorigenic activity is mediated by the induction and inhibition of cancer cell growth and invasion. In a study published in the Journal of Biological Chemistry,
Cancer research
Recent research from Adana, Turkey, demonstrates the effectiveness of prophylactic cranial irradiation (PCI) in reducing or delaying the incidence of brain metastases in locally advanced non-small cell lung carcinoma (LA-NSCLC) patients. A study published in the Journal of Experimental & Clinical Cancer Research found that among 62 patients treated with
Cancer research
Researchers at Okayama University, Japan, have shed light on the impact of EGFR mutation analysis in non-small cell lung cancer (NSCLC). Their study reveals that about 90% of EGFR mutations are clustered in exons 19 and 21, and patients with these mutations show a great response to EGFR-tyrosine kinase inhibitors
Cancer
Researchers in the United States have found that spontaneous tumors in dogs can serve as unique models to study human cancer etiology and therapy. The study focused on the role of the p53 gene, commonly mutated in human cancers, in dog tumorigenesis. The researchers discovered that canine p53 is accumulated
Cancer research
Osteopontin (OPN) has been linked to the formation of malignant pleural effusion (MPE) in lung cancer patients, a poor prognostic sign associated with advanced-stage disease. Research published in Lung Cancer journal reveals that OPN is involved in tumor progression and angiogenesis of lung cancer cells. A study conducted by R.
Cancer
Researchers at Sichuan University in China have discovered that gene therapy may be effective in treating lung cancer in mice. The study, published in Human Gene Therapy, involved injecting mice with a recombinant adenoviral vector carrying the human endostatin gene to inhibit angiogenesis, a key factor in tumor growth. The
Cancer
Scientists in Aarhus, Denmark, have found that interleukin-2 (IL-2) administration may lead to an increase in peripherally circulating FOXP3-positive regulatory immune cells, potentially hindering treatment options for patients with metastatic renal cell carcinoma. The study, published in Clinical Cancer Research, aimed to investigate the impact of IL-2-based therapy on the
Cancer research
Scientists have made significant advances in the understanding of gastric cancer through transcriptome dissection, a detailed analysis of the entire expressed transcripts from a cancer. Researchers have identified novel diagnostic and therapeutic targets for the treatment of gastric cancer by analyzing serial analysis of gene expression (SAGE) libraries. These breakthroughs
Cancer research
Researchers in the Netherlands have successfully tested a novel vaccine, known as the p53 synthetic long peptide (p53-SLP) vaccine, in patients with metastatic colorectal cancer. The study, led by F.M. Speetjens and colleagues from Leiden University, aimed to investigate the safety and immunogenicity of the vaccine. The results showed
Cancer
Researchers in Strasbourg, France have made a significant discovery in the field of cancer gene therapy, shedding light on the role of the von Hippel-Lindau (VHL) tumor suppressor gene in renal cell carcinoma (RCC). According to a report published in Carcinogenesis, the researchers found that parathyroid hormone-related protein (PTHrP) is
