Cancer
A study conducted by researchers at Fudan University in Shanghai, China, has raised concerns about the effectiveness of fluoroquinolone-based oral treatment for low-risk febrile neutropenic patients with cancer. The study, published in BMC Cancer, found that a significant number of Escherichia coli isolates from these patients showed high levels of
Cancer
New research published in the International Journal of Molecular Sciences has shed light on the relationship between genotoxic cancer drugs and checkpoint adaptation, a process that can lead to genomic instability in cancer cells. According to the study, when human cells detect damaged DNA, they initiate a DNA damage response
Cancer
Researchers at Tri-Service General Hospital in Taipei, Taiwan, have investigated the therapeutic effect of an anti-cancer protein, decorin, delivered via an adeno-associated viral (AAV2) gene delivery system in a xenograft U87MG glioma tumor in the brain of nude mice. The study found that decorin expression from the AAV vector inhibited
Cancer
Fresh data on the role of long non-coding RNA HOTAIR in gastric adenocarcinoma have been presented in a new report. Research from Yonsei University in Seoul, South Korea, has found that HOTAIR promotes carcinogenesis and invasion of gastric adenocarcinoma by inhibiting apoptosis and promoting invasiveness. The study highlights the complex
Cancer
A Phase I dose-escalation study, known as GASTANA, has evaluated the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of cabazitaxel in Asian patients with advanced gastric adenocarcinoma who have failed two prior chemotherapy regimens. The study revealed that 15 patients were evaluable for dose-limiting toxicities, with one patient experiencing a
Cancer
A recent study on the P53 pathway has shed new light on the genetic factors that contribute to gastric cancer risk. Researchers at Capital Medical University in Beijing, China, analyzed single nucleotide polymorphisms (SNPs) in the P53 pathway to determine their association with gastric cancer in a hospital-based Chinese Han
Cancer
Researchers from China have conducted a case-control study to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, as well as their interaction with Helicobacter pylori infection and tumor location. The study found that individuals carrying the MTHFR 677TT genotype and those with high folate
Cancer
Recent research on oncology has highlighted the potential of cabozantinib, a novel multiple tyrosine-kinase targeted agent, in anti-angiogenic therapy for the treatment of various solid tumors. The study, conducted by researchers at the College of Pharmacy, revealed that cabozantinib has shown efficacy in inhibiting angiogenesis and cancer growth in preclinical
Cancer
Researchers at the University of Tsukuba in Japan have published a study evaluating the efficacy and safety of S-1 plus oxaliplatin (SOX) as an alternative to cisplatin plus S-1 (CS) in first-line chemotherapy for advanced gastric cancer. The study, which involved 685 patients, found that SOX was noninferior to CS
Cancer
Research from the Institute for Cancer Research and Treatment (IRCCS) in Padua, Italy, has shed light on the role of inflammation in cancer development. The study found that mutant p53, a common mutation in cancer cells, can reprogram TNF signaling through interaction with the tumor suppressor DAB2IP, leading to increased
Cancer
Researchers at the Ludwig Boltzmann Institute for Applied Cancer Research in Vienna, Austria, have shed new light on the molecular mechanisms underlying genomic instability. By investigating the role of unresolved replication intermediates, they found that these structures can block the progression of replication forks and become converted into DNA lesions,
Cancer
Research conducted at the University of Toronto has shed light on the role of claudin 1 in regulating genes involved in cell migration and tumor necrosis factor-alpha (TNF-alpha)-induced gene expression in human gastric adenocarcinoma cells. The study, published in the World Journal of Gastroenterology, found that the knockdown of
