Cancer
Research from the National Cancer Institute highlights the significance of infectious agents in cancer development, with specific examples of human papilloma virus, hepatitis virus, and Epstein-Barr virus contributing to various types of cancer. These agents not only cause genomic instability but also affect the host's immune system, with
Cancer
Research published in Molecular and Cellular Biochemistry has identified that proton particles, a form of ionizing radiation, can cause DNA lesions and alter microRNA (miRNA) expression in mice. The study, led by S.Y. Khan at the University of California, Santa Cruz, examined the effects of whole-body proton irradiation on
Cancer
Scientists at the University of Mons have discovered that the neurotransmitters glutamate, dopamine, and gonadotropin-releasing hormone II (GnRH-II) can significantly enhance the ability of T cells to combat cancer. In head and neck cancer patients, the immune system's T cells are often suppressed, making it difficult for the
Cancer
Cancer has emerged as the deadliest disease in the world, and researchers are racing to understand its complex mechanisms. Recent studies on sphingolipids have shed light on their role in controlling various aspects of cell growth and proliferation in cancer. Sphingolipids, including ceramide and sphingosine-1-phosphate, have been implicated in the
Cancer
MabVax Therapeutics, a clinical stage biotechnology company, has received the Phase 2 portion of the Small Business Innovation Research Grant (SBIR) from the National Cancer Institute (NCI) for the development of its sarcoma vaccine. The grant, valued at $1,752,000 over three years, will support the Phase II clinical
Cancer research
Scientists at the University of Auckland in New Zealand have developed a new compound, ASA404, which has shown great promise in targeting and treating cancer tumors. This compound, an analogue of flavone acetic acid, induces hemorrhagic necrosis of experimental tumors by simultaneously targeting vascular endothelial cells and macrophages within the
Cancer research
New research published in Free Radical Biology & Medicine has found that resveratrol and N-acetylcysteine can block the cancer-initiating step in MCF-10F cells. The study, led by M. Zahid and colleagues from the University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, suggests that these
Cancer
Renal cysts and clear cell renal cell carcinoma are prone to occur in individuals with VHL tumor suppressor gene inactivation. Research published in the Journal of the American Society of Nephrology posits that VHL plays a crucial role in the formation of primary cilia in kidney epithelium. However, the underlying
Cancer
Researchers at the University of Wisconsin-Madison have identified 17 FMRFamide-related peptides in the pericardial organ of Cancer borealis, a type of crustacean. This discovery was made possible by the development of two immunoaffinity-based methods, immunoprecipitation and immuno-dot blot screening assay, which were used in combination with mass spectrometry to characterize
Cancer research
Researchers in Helsinki, Finland have published a study detailing the recognition of DNA damage in nonproliferating human prostate tissue. The study, led by S. Jaamaa and colleagues from the University of Helsinki's Haartman Institute, assessed the response to cytotoxic drugs and ionizing radiation in normal tissue architecture. The
Cancer research
Researchers at the University of Medicine in Timisoara, Romania have discovered that endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is down-regulated in human pituitary adenoma. This study, published in Anticancer Research, investigated the expression of EG-VEGF in 2 samples of normal adenohypophysis and 43 bioptic samples of pituitary adenoma. The
Cancer research
New research from Isparta, Turkey, has investigated the expression of maspin, VEGF, and p53 in patients with squamous cell carcinoma, adenocarcinoma, and small cell lung carcinoma. The study, led by A. Bircan and colleagues from Suleyman Demirel University, aimed to explore the relationship between these markers and clinicopathologic parameters. The
