Scientists
Recent data suggest that erlotinib (Tarceva) and gefitinib (Iressa), tyrosine kinase inhibitors targeting the epidermal growth factor receptor (EGFR), show remarkable activity in a portion of patients with non-small-cell lung cancer (NSCLC). A large randomized controlled trial demonstrated a survival benefit compared to placebo, leading to the US Food and
Cancer research
A new study published in Clinical Cancer Research has shed light on the effectiveness of combining ASA404 (vadimezan; 5,6-dimethylxanthenone-4-acetic acid) with docetaxel in treating castration-refractory metastatic prostate cancer (CRMPC). The randomized phase II study, conducted in the United States, enrolled 74 patients who were previously untreated with chemotherapy. The
Cancer treatment
Research by scientists at Georgetown University's Lombardi Comprehensive Cancer Center has uncovered new findings in the relationship between estrogen receptors and breast cancer risk. A study using genetically engineered mouse models found that both increased expression of estrogen receptor alpha (ER(alpha)) and germline disruption of one p53
Cancer treatment
Researchers at the University of California have developed a new formulation of doxorubicin, a chemotherapy drug commonly used to treat non-Hodgkin's lymphoma (NHL), by conjugating it with a monoclonal antibody that targets the CD22 protein. This new formulation, called CD22-targeted immunoliposomal doxorubicin (IL-PLD), has shown improved efficacy and
Cancer research
Researchers from Sun Yat-Sen University in Guangzhou, People's Republic of China, have made a significant discovery in the field of cervical cancer research, shedding light on the mechanisms underlying tumor progression and metastasis. According to the study, vascular endothelial growth factor C (VEGF-C) plays a crucial role in
Cancer
Research published in the Biochemical and Biophysical Research Communications journal has identified a novel link between p53 family proteins and fibroblast growth factor receptor 3 (FGFR3) expression. Scientists studying the p53 family members, including p53, p63, and p73, found that these proteins regulate FGFR3 expression. This discovery may help understand
Cancer
Researchers at the University of Birmingham have discovered a critical role of CD40 and its ligand (CD40L) in coordinating immune responses, and have found that altering the level of CD40 engagement can induce cell death in carcinoma cells. The team has developed a novel adenovirus that expresses a mutant CD40L
Cancer research
Recent research from Fukuoka, Japan has found that the combination of sorafenib and doxorubicin significantly increases cytotoxicity to renal cell cancer cells, particularly those with high levels of phosphorylated-eIF2alpha and nuclear Nrf2. This study, conducted by M. Shiota and colleagues at Kyushu University's Department of Urology, highlights the
Cancer research
New research published in the journal Oncology Reports has shed light on the role of BCL2L10 in gastric cancer. The study, conducted by R. Mikata and colleagues at Chiba University, investigated the methylation status of BCL2L10 and its expression in gastric cancer tissues and corresponding non-neoplastic mucosae. The findings suggest
Cytological research
A recent study published in Respirology has examined the prognostic value of survivin, X-linked inhibitor of apoptosis protein (XIAP), and second mitochondria-derived activator of caspases (Smac) in advanced non-small-cell lung cancer (NSCLC) patients treated with cisplatin-containing chemotherapy. The study, conducted by researchers at Jiangsu University, found that low expression of
Cytological research
Glioma cells, a type of brain tumor, are notoriously invasive and difficult to treat due to their ability to infiltrate surrounding brain tissue. A recent study from Sun Yat-Sen University in Guangzhou, People's Republic of China, has shed light on the molecular mechanism behind this invasiveness. The researchers
Cancer research
Scientists from the United States have reported new findings in radiation research that show the combination of radiotherapy and anti-CD137 therapy can effectively treat brain tumors in mice. The study, which was published in Radiation Research, involved testing the combination of radiotherapy with an immunotherapeutic approach using an anti-CD137 antibody.
