Cancer
Scientists in Xian, People's Republic of China, have reported a novel approach to enhance radiosensitivity in breast cancer cells using a survivin promoter-driven adenoviral system expressing the PUMA gene. This gene has been identified as a potent proapoptotic molecule, and its overexpression has been shown to induce apoptosis
Cancer research
Researchers at the University of Birmingham have made a breakthrough discovery in the fight against cancer, finding that a previously known anti-cancer drug, dexrazoxane, exhibits powerful anti-angiogenic properties that could revolutionize cancer therapy. In a recently published study, the team demonstrated that dexrazoxane's ability to inhibit the growth
Cancer research
Recent research from Seoul, Korea, has led to the development of a double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus (Ad-DeltaE1B19/55) that, in combination with radiotherapy, shows a significantly enhanced anti-tumor effect. This new therapy triggers tumor cell apoptotic pathways, leading to increased cytotoxicity and higher levels
Cancer
Researchers at Vitro Diagnostics, Inc., a leading biopharmaceutical company, have made significant breakthroughs in adult stem cell products and technology, with applications in cell-based therapy for cancer. The development of novel stem cell technology and products may lead to novel cell therapy for cancer, including treatment of currently untreatable cancer
Cancer
Scientists in Toronto, Canada, have shed light on the mechanisms behind the toxicity and resistance to anticancer therapies involving cisplatin and oxaliplatin. Research conducted by T.J. Preston and colleagues has revealed that oxidative DNA damage, particularly the 7,8-dihydro-8-oxo2'-deoxyguanosine (8-oxodG) lesion, plays a crucial role in the
Cancer research
Investigators in Sendai, Japan have discovered that a new recombinant adenovirus, Adp27-jab-d, expressing a p27(kip1) protein with a deletion of the Jab1-binding region, can induce greater cytotoxicity against human cholangiocarcinoma cells. The Adp27-jab-d virus inhibited the growth of TFK-1 cells in vitro at a concentration 3.3 times lower
Scientists
Scientists in the United States have been investigating new agents in acute myeloid leukemia (AML), a type of blood cancer that remains poorly understood despite advancements in treatment. Traditionally, AML has been treated with anthracyclines and cytarabine, but these approaches have shown limited success, especially for patients with high-risk disease.
Scientists
A multicenter team of childhood cancer researchers has made a groundbreaking discovery by identifying two genetic variations linked to an increased risk for acute lymphoblastic leukemia, or ALL, the most common childhood cancer in the United States. According to University of Florida researcher Meenakshi Devidas, Ph.D., the genetic glitches
Cancer research
A study published in the report "Inside life of melanoma cell signaling, molecular insights, and therapeutic targets" has provided crucial insights into the biology of melanoma, a rapidly growing tumor type in the United States. The researchers identified the V600E "gain-of-function" BRAF mutation as a critical
Scientists
Researchers in the United States have reported a new study on the role of DNA methyltransferases in the epigenetic inactivation of tumor suppressor genes in human cancer. The study, published in the journal Oncogene, used a combination of whole-genome microarray and promoter array analysis to identify genes with altered expression
Scientists
A recent study published in Cancer Prevention Research has found a significant association between higher plasma folate concentrations and a lower risk of cervical intraepithelial neoplasia (CIN) in premenopausal women of childbearing age. The study, led by researchers at the University of Alabama, included 376 women who tested positive for
Cancer research
Researchers at the University of Helsinki have developed an infectivity-enhanced, dual-targeted, and antiangiogenic oncolytic adenovirus for treating kidney cancer. The virus, Ad5/3-9HIF-Delta24-VEGFR-1-Ig, has shown improved specificity and antitumor effect in murine kidney cancer models. The study, published in Gene Therapy, demonstrated that the virus resulted in antitumor efficacy in
