Cancer
Recent studies have identified unique microRNAs (miRNAs) in colonic tumor tissue and blood that may accurately diagnose the presence of colorectal cancer and help predict disease recurrence. Researchers from the University of Leicester, UK have explored the potential role of these biomarkers in the diagnosis, progression, and recurrence of colorectal
Cancer
A new report from researchers at Roswell Park Cancer Institute reveals that the secretion of stress protein grp170 promotes immune-mediated inhibition of murine prostate tumor cells. The study demonstrates that genetic modification of weakly immunogenic murine prostate tumor cells (TRAMP-C2) by stable transfection with a secretable form of endoplasmic reticulum
Cancer
Cancer gene therapy researchers in Guildford, the United Kingdom, have discovered that inhibiting aquaporin 3 increases the sensitivity of prostate cancer cells to cryotherapy. This breakthrough study findings suggest that targeting aquaporin 3 may improve the efficacy of prostate cryotherapy. The researchers used PC-3 and DU145 prostate cancer cells and
Cancer
The Forsyth Regional Cancer Center at Forsyth Medical Center in Winston-Salem, NC is participating in a national trial of the experimental drug Avastin to treat glioblastoma, a fast-growing tumor of the brain or spinal cord. This phase of the trial, testing the effectiveness of Avastin in conjunction with standard chemotherapy
Cancer
Researchers at Hokkaido University's Medical Department conducted a study to investigate the efficacy of combination therapy in treating pancreatic ductal adenocarcinoma (PDAC). The study involved the use of adenovirus vectors to deliver the 4E-BP1 gene, which is a translation repressor, in combination with the mTOR inhibitor rapamycin. The
Cancer research
Scientists in Suzhou, People's Republic of China, have reported a potential new approach to treating pancreatic carcinoma using adenovirus-mediated ING4 expression. The study used a recombinant adenoviral vector, Ad-ING4, which expresses the green fluorescent protein (GFP) marker gene and the tumor-suppressor gene, humanized ING4, derived from murine ING4
Cancer research
Researchers in Taichung, Taiwan have successfully demonstrated the effectiveness of a new immunotherapy approach in treating human cervical cancer. The study, published in the Journal of Biomedical Science, used a recombinant adenovirus-associated vector 2 (rAAV2) expressing human interleukin-15 (hIL15) to inhibit the growth of HeLa cells, a type of cervical
Cancer
Recent research has identified a synthetic tylophorine derivative, PBT-1, as a potential anticancer agent. Investigators at National Taiwan University found that PBT-1 significantly inhibits growth of various cancer cells, including lung cancer, by inducing cell cycle G2/M arrest and apoptosis. The study published in the Journal of Medicinal Chemistry
Cancer
Scientists in Hangzhou, People's Republic of China, have made a groundbreaking discovery in the field of cancer gene therapy. They have developed a highly effective treatment for colorectal cancer by inserting the suppression of tumorigenicity 13 (ST13) gene into a double-regulated oncolytic adenovirus, known as SG500. This innovative
Cancer research
A study from Hangzhou, People's Republic of China, has identified the estrogen receptor-binding fragment-associated gene 9 (EBAG9) as a tumor-promoting factor for renal cell carcinoma and investigated its correlation with primary tumor growth and distant tumor metastasis in a murine breast carcinoma model. The researchers found that knockdown
Cancer research
Scientists at Imperial College London have shed new light on cancer gene therapy with their recent findings published in the journal Oncogene. The study focused on androgen-regulated genes in human LNCaP prostate cancer cells, highlighting the importance of these genes in understanding prostate cancer development and progression. The researchers used
Cancer
Recent research from the University States suggests that topical application of vitamin E may help prevent skin cancer in humans. A study published in Cancer Prevention Research found that healthy human volunteers who applied a cream containing 12.5% vitamin E to their skin showed a significant reduction in the
