Cancer
Research from Kangbuk Samsung Hospital in South Korea has developed a deep learning-based classifier to detect Epstein-Barr virus (EBV) positivity in gastric cancer biopsy and resection specimens. The system, called EBV-TRACER, uses stain normalization to improve accuracy and has been validated on a dataset of 2684 gastric specimens. The results
Cancer
Research published in a recent study has identified a crucial role for mucosal tissue NK cells in maintaining a balance between host protection and tissue repair in localized mucosal tissue infections. The study, conducted by a team of scientists at the Fred Hutchinson Cancer Research Center, used a combination of
Cancer
Researchers at Guangxi Medical University Cancer Hospital have conducted a retrospective study to evaluate the efficacy and safety of zanubrutinib combined with salvage chemotherapy in transplant-ineligible patients with relapsed or refractory (R/R) non-GCB diffuse large B-cell lymphoma (DLBCL). The study found that zanubrutinib combined with either bendamustine and rituximab
Cancer
Research at Chiba University, Japan, has established a connection between Epstein-Barr Virus (EBV) and gastric cancer through the suppression of apoptosis. The study, published in The Journal of Pathology, found that EBV-positive gastric cancers (GCs) exhibit unique carcinogenic pathways that evade apoptosis in the absence of TP53 mutation. The research
Cancer
Researchers have discovered that tumor necrosis factor (TNF) plays a critical role in the development of colorectal cancer (CRC) through cellular reprogramming in intestinal epithelial cells. According to a new report published in Cell Communication and Signaling, prolonged TNF exposure can trigger CRC progression by inducing the expression of doublecortin-like
Cancer genetics
Researchers from the Netherlands Cancer Institute have developed an inducible CRISPR-Cas9 screening platform that allows for precise temporal control over gene editing in non-proliferative states. This breakthrough has been published in Nature Protocols, offering a detailed protocol for researchers to follow. The platform has the potential to be applied across
Cancer
New research published online in the JNCCN-Journal of the National Comprehensive Cancer Network reveals that individuals with cancer who quit smoking have a much lower risk of dying within two years compared to those who continue smoking. The study, which tracked over 13,000 individuals with cancer, found that the
Cancer
Research published in the journal Clinical Genitourinary Cancer has highlighted the increasing incidence of early-stage kidney cancer, leading to a focus on comparative effectiveness research using cancer registry and administrative data. The study, led by Gianpaolo Carpinito and colleagues from the University of North Carolina Chapel Hill, aimed to better
Stomach cancer
Researchers at the University of Verona in Italy have conducted a study on the impact of frailty on postoperative outcomes and protocol adherence in patients undergoing gastrectomy for gastric cancer. The retrospective multicenter study included 957 patients who underwent gastrectomy within an enhanced recovery protocol (ERP) between 2018 and 2024.
Cancer
Research at Chiba University, Japan, has established a connection between Epstein-Barr Virus (EBV) and gastric cancer through the suppression of apoptosis. The study, published in The Journal of Pathology, found that EBV-positive gastric cancers (GCs) exhibit unique carcinogenic pathways that evade apoptosis in the absence of TP53 mutation. The research
Cancer
Research has identified that gastric cancer patients with poor preoperative nutritional status have significantly reduced overall survival rates. The study, conducted at Fujian Medical University, analyzed data from 19,285 patients from 27 global cohorts between 2016 and 2023. The Prognostic Nutritional Index (PNI) and Nutritional Risk Screening 2002 (NRS-2002)
Cancer
Researchers at Amity University Uttar Pradesh have highlighted the critical role of membrane transporters in cancer, noting that their expression is frequently reprogrammed to support enhanced growth, survival, and therapy resistance. These transporters, regulated by the tumor suppressor p53, facilitate the uptake and efflux of nutrients, ions, and drugs, making
