Cancer

Cancer

New Insights into Doxorubicin Therapy: Research Reveals Role of NETs in Cardiotoxicity

Research conducted at Sun Yat Sen University Cancer Center has unveiled a crucial link between neutrophil extracellular trap (NET) DNA and cardiotoxicity in patients undergoing anthracycline-containing treatment. The study discovered that doxorubicin, a common chemotherapy drug, induces HMGB1-dependent cardiac NET formation, promoting cardiac remodeling and dysfunction. The researchers identified a