Cell death
Research conducted by scientists at South Dakota State University has revealed a significant role of the c-Jun N-terminal kinase (JNK) in regulating cell death. The study published in npj Systems Biology and Applications found that JNK activation dynamics induce distinct gene expression patterns, mediated by mRNA stability. The findings highlight
Cell death
Research conducted by scientists at South Dakota State University has revealed a significant role of the c-Jun N-terminal kinase (JNK) in regulating cell death. The study published in npj Systems Biology and Applications found that JNK activation dynamics induce distinct gene expression patterns, mediated by mRNA stability. The findings highlight
Biochemistry
Research conducted at the Institute for Biomedical Engineering in Tianjin, China, has led to the development of nanoparticles that can reprogram tumor-associated macrophages to fight cancer. The study, published in Biomaterials Science, shows that the nanoparticles can induce immunogenic cell death of tumor cells, activate dendritic cells, and initiate T
Biochemistry
A recent study published in Signal Transduction and Targeted Therapy has revealed that influenza A virus (IAV) induces PANoptosis, a form of lytic inflammatory cell death, in macrophages. The research, conducted by a team of scientists at the China-Japan Friendship Hospital, found that Ninjurin-1 (NINJ1), a mediator of plasma membrane
National Academy of Sciences
Scientists at Colorado State University have unveiled a breakthrough in the field of Immunology, detailing the creation of artificial interleukin receptors that can be designed and engineered to elicit specific immune responses. This research, published in the Proceedings of the National Academy of Sciences, marks a significant step forward in
Cell death
Scientists at La Trobe University have made a groundbreaking discovery about the way viruses spread around the body, potentially leading to more effective drug development for various diseases. The research, published in Nature Communications, sheds new light on the process of cell death and renewal. By uncovering a previously unknown
Cell death
Scientists at La Trobe University have made a groundbreaking discovery about the way viruses spread around the body, potentially leading to more effective drug development for various diseases. The research, published in Nature Communications, sheds new light on the process of cell death and renewal. By uncovering a previously unknown
Cancer research
Researchers at the Institute of Cancer Research, London, have discovered that a combination of two targeted drugs may help treat up to two in five advanced prostate cancer patients. The drugs, which are already in development or approved for use in other cancers, were found to slow tumour growth and
Cancer patients
Scientists at The Institute of Cancer Research, London, have made a groundbreaking discovery in the treatment of advanced prostate cancer. By combining two existing drugs, they have found a way to slow tumour growth and trigger cancer cell death in up to 40 per cent of patients with late-stage disease.
Biochemistry
Researchers from the University of Utah have made a groundbreaking discovery in the field of oncology, specifically in the treatment of melanoma. They have developed a polymer-based chemo-immunotherapy strategy that combines immune checkpoint inhibitor (ICI) monotherapy with a multivalent HPMA copolymer-peptide antagonist of PD-L1 (PPA). This innovative approach has shown
Biochemistry
Researchers at Shenzhen University Medical School have made a significant discovery in the field of leukemia treatment, highlighting the importance of inflammatory cell death mechanisms in controlling the disease. According to the study, inflammatory cell death can suppress tumor growth and aid in leukemogenic processes, while also providing a potential
Biochemistry
Research conducted at the National Cancer Institute has shed new light on the role of Kaposi sarcoma-associated herpesvirus (KSHV) protein K5 in preventing cell death during lytic replication. The study, published in the Journal of Virology, found that K5 is a substrate for caspases and plays a crucial role in
