Cancer genetics
Researchers at Yale University School of Medicine have made significant progress in cancer gene therapy by developing a novel delivery system for triplex-forming oligonucleotides (TFOs). The study, published in Molecular Therapy - Nucleic Acids, utilized a lupus-derived anti-DNA monoclonal antibody, 3E10, to target and deliver TFOs into the nucleus of
Proteins
Researchers at the Faculty of Medicine have conducted a genome-wide screen in yeast to identify additional proteins involved in mitoRQC, a process that protects mitochondria against toxic proteins. The study found that peptidyl-tRNA hydrolase 2 (Pth2), present in the mitochondrial outer membrane, influences aggregation of CAT-tailed proteins without affecting the
Adult respiratory distress syndrome
Research conducted at Tongji University in Shanghai, People's Republic of China, has shed new light on the role of itaconate in inflammatory diseases, particularly in acute lung injury. According to the study, itaconate promotes the production of proinflammatory cytokines and augments the activation of the NACHT-, leucine-rich-repeat- (LRR)
University of California
New research from the University of California San Francisco (UCSF) has shed light on the molecular identity of wound signals and their receptors on nociceptors, a type of sensory receptor cell that detects harsh touch, heat, and UV light. The study, published in the journal Neuron, identifies Vulnusin, an endogenous
Chromatin
Researchers at Harvard Medical School have made groundbreaking discoveries about the essential activity of histone chaperones during eukaryotic transcription elongation. A highly conserved process, histone chaperones are responsible for assembling and disassembling nucleosomes to maintain chromatin integrity. This intricate dance of molecular chaperones is critical for transcription elongation, a process
Cell Press
Researchers at Editas Medicine have made a significant breakthrough in gene editing technology, using the enzyme AsCas12a to induce fetal hemoglobin production in patients with sickle cell disease and beta-thalassemia. The study, published in Molecular Therapy, found that AsCas12a-edited cells exhibited long-term, multi-lineage, and polyclonal engraftment in immunocompromised mice, and
Cell Press
Researchers at Editas Medicine have made a significant breakthrough in gene editing technology, using the enzyme AsCas12a to induce fetal hemoglobin production in patients with sickle cell disease and beta-thalassemia. The study, published in Molecular Therapy, found that AsCas12a-edited cells exhibited long-term, multi-lineage, and polyclonal engraftment in immunocompromised mice, and
Cell Press
Researchers at Harvard Medical School have identified tissue fluidity as a crucial regulator of adhesion-based sorting in multicellular patterning. According to a new study published in the Biophysical Journal, tissue fluidity - the ability of cells to move freely within a tissue - is essential for the sorting process to
Adult respiratory distress syndrome
Research conducted at Tongji University in Shanghai, People's Republic of China, has shed new light on the role of itaconate in inflammatory diseases, revealing a previously unknown proinflammatory function in tissue-resident alveolar macrophages. The study, published in Cell Metabolism, found that itaconate promotes the production of proinflammatory cytokines
Cardiovascular equipment
Researchers at the National Heart Lung and Blood Institute (NHLBI) have discussed new findings in biotechnology, specifically in gene therapy, to address the complexity of sickle cell disease (SCD). According to the research, SCD is a range of genotypes that result in a clinical syndrome affecting nearly every organ system,
