Cancer
Dylan Williams, a 14-year-old boy diagnosed with Non-Hodgkin Lymphoma, has been showered with support from his local community and beyond. As he undergoes chemotherapy and lumbar punctures, his family receives an outpouring of love and financial assistance. The Inverness Royal Academy pupil's father, Barry, notes that Dylan is
Cancer
Researchers from Xi'an Jiaotong University have made a significant breakthrough in cancer gene therapy using engineered bacteria as intelligent microbots. These microbots, modified with drug-loaded liposomes, are designed to preferentially target and colonize tumors, overcoming the poor delivery efficacy of nanomedicines. The study, published in the journal Small,
Cancer
A recent phase 3 study presented at the International Conference on Malignant Lymphoma has demonstrated the potential of combining the CD20xCD3 bispecific Lunsumio and the CD79b-directed ADC Polivy in treating large B-cell lymphoma (LBCL). The Lunsumio-Polivy regimen showed a significant reduction in the risk of progression or death, compared to
Cancer research
Long-term survivors of childhood cancer are at increased risk of developing subsequent neoplasms (SNs), particularly those exposed to radiotherapy and chemotherapy, as well as those with genetic predisposition. This risk is substantial, with cancer treatments and genetic risk jointly contributing to a substantial proportion of incident SN cases. The study,
Cancer
A study published in Molecular Cell has shed light on the function of YTH domain family protein YTHDF2, which plays a previously unknown role in cancer progression. Researchers from the Third Affiliated Hospital of Chongqing Medical University demonstrated that YTHDF2 enhances protein synthesis in tumor cells by forming interactions with
Cancer research
A study conducted at Ain Shams University in Cairo, Egypt, has shown that a cardiac rehabilitation program can significantly reduce the risk of chemotherapy-induced cardiotoxicity in patients with breast cancer. The researchers, led by Ahmed K. Araquib, used two-dimensional speckle tracking echocardiography to assess the effects of the program on
Cancer research
Researchers at the Fred Hutchinson Cancer Research Center have made a groundbreaking discovery that challenges our understanding of the microbiome and its role in the human body. By analyzing paired oral and fecal samples from patients undergoing intensive chemotherapy, scientists found that oral bacteria are indeed present in the colon,
Chemotherapy
IMUNON, Inc. has unveiled promising Phase 2 translational data for its gene-based interleukin-12 (IL-12) immunotherapy, IMNN-001, in patients with newly-diagnosed, advanced ovarian cancer. The OVATION 2 Study demonstrated significant increases in IL-12, interferon-gamma, and tumour necrosis factor-alpha levels within the tumour microenvironment. These findings highlight the therapy's tumour-targeted
Cancer
Pembrolizumab, a PD-1 inhibitor, has shown potential in increasing tumor-infiltrating lymphocytes and promoting local tumor immunologic recruitment, according to a pilot study published in Gynecologic Oncology Reports. The study, conducted by researchers at the Duke Cancer Institute, assessed the feasibility, toxicity, and changes in immune parameters in response to one
Cancer
Researchers from Liaoning Cancer Hospital and Institute have made a groundbreaking discovery in the field of immunotherapy, developing a novel artificial intelligence (AI) model that accurately predicts pathological response to neoadjuvant chemo-immunotherapy in non-small-cell lung cancer (NSCLC). The study, published in the Journal for ImmunoTherapy of Cancer, utilized a retrospective
Cancer
The Uganda Cancer Institute's Center for Natural Therapeutics (CENAT) has developed seven herbal products with potential to prevent cancer, shrink tumors, and alleviate the side effects of conventional treatment. The products, still under investigation, have shown promising early results and will undergo clinical trials. CENAT aims to provide
Cancer research
Research has shed light on the factors contributing to chemotherapy-related cognitive impairment in elderly lung cancer patients. A study conducted in Chongqing, People's Republic of China, investigated the potential factors and created an intervention program aimed at enhancing the cognitive abilities of this vulnerable population. The study found
