Clinical trials
Researchers from Oklahoma State University Center for Health Sciences have conducted a systematic review to assess the clinical usefulness and transparency of knee arthroplasty randomized controlled trials (RCTs) published between 2020 and 2024. The study aimed to evaluate the utility of TKA RCTs using the van't Hooft framework
Clinical trials
Researchers at the National Research Centre in Egypt have found that Wharton's jelly-derived mesenchymal stem cell exosomes can effectively treat diabetic foot ulcers. The treatment showed a significant improvement in wound healing outcomes, with 62% of patients fully recovering within 6 weeks. The study also found that the
Business research
The global Diabetic Foot Ulcers (DFUs) pipeline has been growing rapidly, with numerous companies working on novel therapies to treat this debilitating condition. According to a recent report by DelveInsight, there are 20+ key companies developing 25+ DFUs treatment therapies, with a focus on advancing the pipeline products from the
Clinical trials
A new pilot study evaluating the individual videoconference version of a program for people with Parkinson's disease (PD) has been published in the Journal of Parkinson's Disease. The study aimed to assess the feasibility and preliminary effectiveness of the program in reducing fatigue and improving quality
Clinical trials
Clinical trials investigating oncology drug development rely heavily on time-to-event endpoints such as progression-free survival (PFS) and overall survival (OS) to assess therapeutic efficacy. However, the accuracy and interpretability of these endpoints can be compromised by various factors, including protocol design, intercurrent events, inconsistent data collection, and missing follow-up data.
Clinical trials
Current research from the National Cerebral and Cardiovascular Center in Suita, Japan, suggests that existing treatments for dementia may only delay cognitive deterioration without improving cognitive function. This conclusion is based on preliminary findings from a randomized, double-blind, placebo-controlled trial involving 60 patients with mild cognitive impairment or mild dementia.
Clinical trials
Researchers from the Kansas City Orthopedic Alliance have developed a novel, minimally invasive technique for repairing Achilles tendon ruptures using ultrasound guidance and a knotless barbed suture. According to a study published in the Journal of Medical Ultrasonics, this new approach has shown promising results in a cadaveric model, demonstrating
Clinical trials
A recent study has found that a vegan diet may help individuals with type 1 diabetes reduce their insulin use and costs. The study, published in BMC Nutrition, analyzed the effects of a vegan diet compared to a portion-controlled diet on insulin use and insulin costs in people with type
Clinical trials
A new study has shed light on the vast potential of in-silico clinical trials (ISCTs) in medical device development, particularly in the integration of computational modeling and simulation (CM&S), artificial intelligence (AI), and machine learning (ML). Researchers have evaluated regulatory advancements by the FDA, EMA, and PMDA, identified
Clinical trials
Researchers at the Department of Research, led by Gitanjali Talele, have published a study investigating the safety, efficacy, and immunogenicity of an oral homeopathic SARS-CoV-2 nosode, BiosimCovex, in preventing COVID-19 infection. The phase III, multicentre, randomized, double-blind, placebo-controlled trial involved 2671 unvaccinated participants from 13 sites in India. Participants received
Cattle
The Animal and Plant Health Agency (APHA) has confirmed that the CattleBCG vaccine and its accompanying DIVA skin test are being tested on a large scale on commercial farms in England and Wales, marking a significant milestone in the fight against bovine tuberculosis (bTB). The vaccine, if successful, could provide
Clinical trials
Sanofi has scrapped its respiratory syncytial virus (RSV) vaccine for toddlers, dubbed SP0125, after an independent data monitoring committee (IDMC) determined that it was unlikely to demonstrate suitable efficacy in a late-stage study. The intranasal live attenuated vaccine was being evaluated in a phase 3 study involving approximately 6,300
