Clinical trials
Research has been conducted to evaluate the effect of positive end-expiratory pressure (PEEP) combined with 100% oxygen on atelectasis during emergence from anesthesia after one-lung ventilation (OLV) with a bronchial blocker in infants receiving thoracoscopic lobectomies. The study aimed to assess whether the use of PEEP with 100% oxygen could
Clinical trials
Researchers have highlighted the need for more representative and inclusive clinical trials that account for the unique needs of pregnant and lactating individuals. According to a recent study, there is a lack of knowledge among health care providers and patients about clinical trials during pregnancy, making it challenging to engage
Clinical trials
Investigators at Babol University of Medical Sciences, Iran, conducted a randomized clinical trial to compare the effects of massage, chicory bath, and phototherapy on bilirubin levels in term newborns. The study, published in BMC Pediatrics, found that massage therapy combined with phototherapy was more effective in reducing the length of
Clinical trials
A new study published in Acta Paediatrica has shed light on the reasons behind parental decline of participation in neonatal clinical studies. The research, conducted between June 2022 and April 2023, aimed to explore the factors influencing parents' decisions to decline participation in a study investigating the transfer of
Clinical trials
Research findings have shed light on the potential of oncolytic virotherapy in treating recurrent head and neck cancer. A recent study published in Virus Research has demonstrated the efficacy and safety of a novel therapeutic approach using VT1093, an oncolytic recombinant herpes simplex virus type 1 engineered to express a
Clinical trials
Research conducted by Genentech Inc.'s IQ DILI Initiative highlights the need for guidance in evaluating liver tests due to COVID-19, its treatments, and vaccination. The study emphasizes the variability of liver-related manifestations in non-hospitalized patients and the potential for liver injury to occur even after symptoms resolve. The
Clinical trials
Research conducted at Maastricht University, in collaboration with Dutch care organizations, has explored the potential benefits of smart continence care (SCC) for individuals with profound intellectual and multiple disabilities. The study, which used a cluster randomized trial design, investigated the cost-effectiveness and cost-utility of SCC compared to regular continence care
Clinical trials
New patient-reported outcomes data from the Phase 3 VERITAC-2 clinical trial evaluating vepdegestrant, a novel investigational PROTAC estrogen receptor degrader, demonstrated statistically significant improvements in overall quality of life, pain, and multiple functioning domains compared to fulvestrant in patients with ESR1-mutated ER+/HER2- advanced or metastatic breast cancer. These findings
Clinical trials
A groundbreaking study published in Biometrics aims to revolutionize the approach to dose selection in clinical trials. The US Food and Drug Administration (FDA) has launched Project Optimus to shift the focus from the maximum tolerated dose to the optimal biological dose (OBD). This new approach seeks to optimize the
Clinical trials
Researchers from University Medical Center Hamburg-Eppendorf, Germany, conducted a randomized clinical trial to evaluate the effectiveness of a self-help smartphone app designed to reduce depressive symptoms and improve self-esteem and quality of life in individuals with intellectual disabilities. The study involved 99 participants, who were randomly assigned to either the
Clinical trials
Researchers at the University of Southern Denmark conducted a double-blinded, randomized controlled efficacy trial to examine the effectiveness of a smartphone-based serious gaming app, Brain+ Alco-Recover, in addressing cognitive impairments associated with alcohol use disorder (AUD). The study, published in JMIR Mental Health, involved 72 outpatients with AUD who were
Clinical trials
A newly developed radiopharmaceutical composition, created by inventors Jalomaki and Seppanen, has shown significant promise in treating prostate cancer with lower rates of toxicity. The composition, which targets prostate-specific membrane antigen (PSMA), has been designed to provide a safer and more effective treatment option for patients with metastatic castration-resistant prostate
