Communicable diseases
In the wake of the Ebola outbreak resurfacing in the Kasaï province of the Democratic Republic of Congo, the Republic of Congo is ramping up its health security measures to prevent the spread of the disease. With the Congo River connecting communities on both sides, hundreds of passengers cross the
Communicable diseases
As part of a new international research consortium, scientists from around the world are coming together to better understand the deadly Rift Valley fever virus and its impact on Africa. This effort, led by the Kilimanjaro Clinical Research Institute in Tanzania, aims to study the virus in Tanzania, South Africa,
Communicable diseases
Research from Central University of Haryana sheds light on the significance of vitamin D in preventing and managing non-communicable diseases such as cancer, osteomalacia, diabetes, and cardiovascular diseases. The study emphasizes the importance of a balanced diet and supplements in maintaining sufficient vitamin D levels, which is crucial for regulating
Communicable diseases
Researchers from Curtin University and The Kids Research Institute Australia have conducted a groundbreaking study mapping tuberculosis (TB) cases in Africa, which could potentially improve diagnosis, treatment, and prevention of the disease worldwide. The team used data from 50 surveys covering over 1.5 million people examined for TB to
Drugs
SGX523, a novel ATP-competitive kinase inhibitor, has been shown to exhibit exquisite selectivity for the MET receptor tyrosine kinase, making it a promising tool for cancer research. Researchers report that SGX523 potently inhibits MET with an IC50 of 4 nmol/L, demonstrating 1,000-fold selectivity versus other protein kinases tested
Drugs
In a remarkable case, a patient with advanced renal cell carcinoma (RCC) achieved complete remission after undergoing adoptive immunotherapy using activated autologous gammadelta T-cells. The 2-year remission milestone, with no additional treatment required, is a significant breakthrough in cancer gene therapy. Researchers at Tokyo Women's Medical University, led
Drugs
Research published in the Oncology Reports journal has found that resveratrol, a compound found in red wine and several other plant-based foods, can induce apoptosis in multidrug-resistant human lung cancer cells. The study, conducted by W. Zhao and colleagues from the Chinese PLA General Hospital, Department of Respiratory Medicine, involved
Drugs
In a landmark study published in Biochimica Et Biophysica Acta, researchers from Harvard University and Dana-Farber Cancer Institute have shed light on the structural and mechanistic underpinnings of EGFR mutations in non-small cell lung cancer. The study explores the exquisite sensitivity of a subset of lung cancer mutants to gefitinib
Drugs
Recent research from Madrid, Spain, reveals that non-small-cell lung cancer (NSCLC) accounts for approximately 80%-85% of all cases of lung cancer, with stage III disease making up around 40% of all cases. For patients with unresectable stage III NSCLC, the treatment typically involves a combination of platinum-based chemotherapy and
Scientists
Researchers at Northwestern University have discovered that IL-17, a cytokine previously known for its role in autoimmune diseases, plays a novel role in mediating angiogenesis in rheumatoid arthritis (RA). The team, led by S.R. Pickens, found that local expression of IL-17 in mouse ankles increases vascularity, and that IL-17
Scientists
Scientists in the Netherlands have conducted a study to implement a 3D dose verification procedure for lung cancer patients treated with stereotactic body radiotherapy (SBRT). The method uses in-room cone-beam CT imaging and portal dosimetry to ensure accurate dose delivery. The researchers found that the procedure is independent of the
Drugs
Researchers from Nanjing, People's Republic of China, have made a significant discovery in the field of cancer gene therapy. By down-regulating the expression of heat shock protein 27 (HSP27), the team was able to sensitize TRAIL-resistant tumor cells to TRAIL-induced apoptosis. This breakthrough has important implications for the
