Cytokines
Researchers at the University of Kansas Medical Center have made a significant discovery in the field of cytokines and intercellular signaling peptides and proteins. Their study, published in the International Journal of Molecular Sciences, reveals that misregulation of C-C chemokine receptor 7 (CCR7) has been linked to multiple autoimmune diseases,
Cytokines
A new study examining the effects of cytokine-filtered continuous renal replacement therapy (CRRT) on sepsis patients reveals that hemogram-derived indices, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), may reflect treatment-related effects rather than disease progression. The research, conducted at a single tertiary care center in Istanbul, Turkey,
Atopic dermatitis
Current research results on skin diseases and conditions - atopic dermatitis have been published, reevaluating the cellular sources of IL-13, a key effector cytokine in AD lesions. This review reappraises the traditional paradigm of CD4 Th2 cells as the primary producers of IL-13 in AD, instead highlighting the substantial contribution
Cytokines
Investigators have shed new light on the complex relationship between the gut microbiota, inflammatory factors, and irritable bowel syndrome (IBS). A recent study, published in the journal Neurogastroenterology & Motility, identified a potential causal association between the gut microbiota and IBS. The research suggests that manipulating the gut microbiota may
T cells
Researchers at Mayo Clinic Arizona have made significant progress in addressing the limitations of chimeric antigen receptor (CAR) T cell therapy in treating solid tumors. The study, published in Frontiers in Immunology, introduces a new class of engineered receptors that modulate T cell activity independently of direct antigen recognition. Chimeric
T cells
Research conducted at Gyeongsang National University in South Korea has shed light on the optimal priming conditions for canine mesenchymal stem cells (cAMSCs), which have been widely studied for their immunomodulatory abilities in treating immune-mediated diseases. The study, funded by the National Research Foundation (NRF) of Korea, aimed to investigate
T cells
Researchers at Mayo Clinic Arizona have made significant progress in addressing the limitations of chimeric antigen receptor (CAR) T cell therapy in treating solid tumors. The study, published in Frontiers in Immunology, introduces a new class of engineered receptors that modulate T cell activity independently of direct antigen recognition. Chimeric
Cytokines
Investigators from the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China, have made significant discoveries in the field of ovarian cancer, a highly malignant gynecological tumor with a dismal 5-year survival rate. The research, published in the journal Gene, explored the role
Chemotherapy
Researchers at the First Affiliated Hospital of Jinan University have identified the dual roles of chemotherapy in modulating cytokine dynamics in ovarian cancer, providing valuable insights for addressing resistance and improving combination therapies. The study, published in the International Journal of Cancer, reveals that platinum-based agents and taxanes can trigger
Cytokines
Research at Monash University has shed new light on the underlying mechanisms of drug-resistant epilepsy (DRE). By comparing plasma inflammatory biomarkers and monocyte phenotypes in patients with DRE and psychogenic non-epileptic seizures (PNES), researchers identified potential therapeutic targets for the development of new treatments. The study, published in Scientific Reports,
Cystic fibrosis
Researchers at the Medical University of Innsbruck have made a groundbreaking discovery in the field of cystic fibrosis, providing new insights into the immune response of patients with mild lung disease. According to a recent study published in the International Journal of Molecular Sciences, the measurement of cytokines in induced
