Diseases
A team of researchers has made significant strides in developing a more effective assessment tool for Parkinson's disease, specifically targeting early-stage patients. By applying a cross-sectional Rasch model to the Parkinson's Progression Markers Initiative (PPMI) untreated PD cohort data, the team identified a sub-score of 15
Diseases
Levicept, a UK-based biotechnology company, has reported new data from its Phase II trial of LEVI-04, a first-in-class treatment for osteoarthritis (OA). The clinical trial, which enrolled 518 participants, demonstrated significant, dose-dependent reductions in bone marrow lesions (BML) compared to placebo. The findings suggest that LEVI-04 may have disease modification
Diseases
Lived experience research provides a unique perspective on suicidality, offering insights that can inform effective mental health care and policies. A recent study conducted by researchers at the University of Melbourne highlights the importance of involving those personally affected by suicidality in research to strengthen its relevance and impact. The
Bictegravir
Researchers at the Centers for Disease Control and Prevention (CDC) have published a study on HIV postexposure prophylaxis (PEP) use in the United States, highlighting a significant increase in PEP prescriptions from 2015 to 2023. The study analyzed national trends in PEP regimens recommended by the CDC, as well as
Diseases
A recent study by researchers from the University of New South Wales has shed light on the experiences of Syrian mental health and psychosocial support service users in Northwest Syria and Turkey. The research, supported by the ELRHA's Research for Health in Humanitarian Crises (R2HC) Program, UK Foreign,
Diseases
By 2050, an estimated 25.2 million people will be living with Parkinson's disease, a 3-fold increase from the 8.5 million cases in 2023. While the disease has no cure, new research suggests that certain lifestyle factors, such as moderate exercise, a healthy diet, and avoidance of
Addiction
A new study on mental health diseases and conditions has revealed critical insights into the developmental stages of mental illness among youth. The research, conducted by the Centre for Addiction and Mental Health, highlights the importance of early intervention for youth with complex mental illness. This comprehensive review aims to
Diseases
Researchers at the Walter and Eliza Hall Institute of Medical Research have discovered that autoantibodies, specifically targeting type I interferons, are a key feature in severe COVID-19 cases and hospitalizations. The study found that hospitalized patients had significantly higher levels of autoantibodies targeting various proteins, including ACE2, MPO, IFNO, IFNa1,
Diseases
Researchers from the Centers for Disease Control and Prevention (CDC) have announced a new HIV preexposure prophylaxis (PrEP) option that has shown high efficacy and safety in US clinical trials. According to the CDC, the injectable medication, lenacapavir (LEN), administered every 6 months, has been approved by the Food and
Diseases
A recent study published in BMC Surgery has shed light on the effectiveness of the bowel-first approach in treating intra-abdominal penetrating Crohn's disease. Researchers from Zhejiang University conducted a retrospective cohort study of adult patients with penetrating CD who underwent elective intestinal resection between January 2019 and December
Diseases
The largest randomized Drug Eluting Balloon trial, SELUTION DeNovo, has shown that a SELUTION SLR(TM) DEB treatment strategy is non-inferior to a systematic DES treatment strategy in real-world coronary de novo lesions. The trial, which enrolled 3,323 patients across 62 international sites, demonstrated a target vessel failure (TVF)
Diseases
Experts from Universita Cattolica, Rome campus, and Roma Tre University have made a significant discovery in the realm of cellular energy balance, identifying a key switch called phosphatase B55 (PP2A-B55alpha) that regulates the balance of mitochondria. This breakthrough could lead to new therapies for diseases ranging from Parkinson's
