Drug resistance - Strategic Insights Report

Enzymes

Quorum Quenching by Endophytic Bacillus cereus AL1: A Lactonase-Based Anti-Virulence Strategy Against Pseudomonas aeruginosa

Researchers at Future University in Egypt have isolated an endophytic bacterium, Bacillus cereus AL1, which exhibits significant anti-virulence activity against Pseudomonas aeruginosa. The study, published in BMC Microbiology, highlights the potential of Bacillus cereus AL1 lactonase as an effective anti-virulence agent against Pseudomonas aeruginosa without the pressure for resistance development.

Antiviral agents

RNA Viruses - Influenza A Virus Subtype H1N1 Research Uncovers New Treatment Insights

Researchers at the University of Hong Kong have made significant progress in understanding the characteristics of influenza A virus subtype H1N1 and the effectiveness of various antiviral treatments. Investigating the virus's mutations and responses to different medications, the team assessed the efficacy of oseltamivir, molnupiravir, and baloxavir treatments

Drug resistance

Spatial Clusters of Dominant Lineages of Uropathogenic Escherichia coli Revealed

Research published in BMC Infectious Diseases has shed light on the presence of spatial clusters of dominant lineages of uropathogenic Escherichia coli (UPEC) in a community-dwelling patient population. According to the study, 45% of UPEC isolates were identified as pandemic ST lineages, with ST131 being the most prevalent and contributing

Drug resistance

Quorum Quenching by Endophytic Bacillus cereus AL1: A Lactonase-Based Anti-Virulence Strategy Against Pseudomonas aeruginosa

Drug resistance

Multidrug Resistant Tuberculosis Remains Public Health Threat in China

Researchers from Ningbo University of Finance and Economics have published a new report on the ongoing public health threat posed by multidrug-resistant tuberculosis (MDR-TB) in China. The study, which analyzed data from patients enrolled between 2015 and 2021, identified several risk factors associated with hospital readmission for MDR-TB patients. The

Antiviral agents

RNA Viruses - Influenza A Virus Subtype H1N1 Research Uncovers New Treatment Insights

Drug resistance

Multidrug Resistant Tuberculosis Remains Public Health Threat in China

Aquaculture industry

Antimicrobial Resistance in Fish Farms: A Growing Concern

Researchers from the Department of Animal Science have conducted a comprehensive study on the knowledge, attitudes, and practices of fish farmers regarding antimicrobial use and resistance in Cameroon. The study aimed to assess the level of awareness among fish farmers about the risks associated with antimicrobial resistance (AMR) and their

Drug resistance

Tuberculosis Treatment Outcomes in South Africa: Analysis of Multidrug-Resistant Cases

Researchers from the University of KwaZulu-Natal have conducted a retrospective study to assess treatment outcomes of patients receiving the nine-month short regimen for rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) in uMkhanyakude District, South Africa. The study, published in BMC Infectious Diseases, aimed to identify socio-demographic and clinical factors associated with

Drug resistance

Quorum Quenching by Endophytic Bacillus cereus AL1: A Lactonase-Based Anti-Virulence Strategy Against Pseudomonas aeruginosa

Bedaquiline

Variability in Intrinsic Drug Tolerance in Mycobacterium tuberculosis Corresponds with Phylogenetic Lineage

A new study has shed light on the relationship between variability in intrinsic drug tolerance in Mycobacterium tuberculosis (Mtb) and its phylogenetic lineage. The research suggests that certain strains of Mtb are more intrinsically drug-tolerant and more readily evolve drug resistance. This has significant implications for the treatment of tuberculosis

Antiviral agents

RNA Viruses - Influenza A Virus Subtype H1N1 Research Uncovers New Treatment Insights

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