Drug resistance
Research from Moldova State University has highlighted the behavioral differences between individuals with drug-resistant epilepsy and those with well-controlled epilepsy. A study published in Psihologie, a journal of the Association of Psychologists Practitioners, Moldova, analyzed 102 participants with epilepsy, finding statistically significant differences in aggression, hostility, and shyness between the
Drug resistance
A recent publication in the Epilepsia journal highlights the effectiveness of VNS Therapy in reducing the frequency of generalized tonic-clonic seizures in patients with drug-resistant epilepsy (DRE). The 24-month data from the CORE-VNS study shows a median seizure reduction of 77% and 43% of participants reporting seizure freedom. These findings
Drug resistance
A new report published in Pediatric Neurosurgery provides insight into the post-operative burden of musculoskeletal (MSK) disease in paediatric patients undergoing hemispherectomy, hemispherotomy, or lobectomy for drug-resistant epilepsy. Research conducted at the University of California Los Angeles (UCLA) reveals that 45.2% of patients developed new MSK conditions post-operatively, with
Clinical trials
Ananda Developments Plc has announced that its cannabis-based medicines, MRX2 (CBD) and MRX2T (CBD+THC), will be used in two major NHS-backed phase IIIa trials exploring treatments for drug-resistant epilepsy. The trials aim to test whether the medicines can reduce seizures and improve participants' quality of life in patients
Drug resistance
Research conducted at the International University has shed new light on the complex etiologies of developmental and epileptic encephalopathy (DEE) and metabolic epilepsy (ME) in neonatal intensive care units. By analyzing the genetic abnormalities of 59 patients using exome sequencing, the study identified 40 genetic abnormalities, including de novo variants,
Drug resistance
A devastating report has been published in The Lancet, warning that antimicrobial resistance (AMR) could lead to the deaths of 40 million individuals within the next 25 years. The scientists behind the study have emphasized the urgent need for action to prevent this catastrophic outcome. The research, which spans from
Drug resistance
A review of targeted therapies in treating multiple myeloma has highlighted the complex nature of the disease and the potential of novel treatments. Led by experts Qizhong Lu, Donghui Yang, Ting Niu, and Aiping Tong, the study explores the key signaling pathways that drive the progression of myeloma, including the
Comorbidity
Despite over 30 marketed antiseizure medications (ASMs), approximately 30 percent of epilepsy patients continue to experience seizures that are not completely managed by available therapies. The urgent need to revamp therapy discovery strategies has led to a pivotal shift in the approach to treating drug-resistant epilepsy. Recent advances in genetic
Comorbidity
Research has found that patients with drug-resistant epilepsy exhibit a high frequency of Axis I comorbid psychiatric disorders, including depression and anxiety disorders, with a significant association of comorbid depression and impulsivity. A study conducted at the University of Buenos Aires analyzed patients with temporal lobe epilepsy and extra-temporal epilepsy,
Drug resistance
People with drug-resistant epilepsy, a condition where standard treatments are ineffective, face significant challenges in increasing their physical activity, a crucial aspect for overall health. Research from Wake Forest University School of Medicine has highlighted these barriers, including low appeal of exercise interventions, comorbid mental health struggles, and fear of
Drug resistance
Research conducted at the Universita Cattolica del Sacro Cuore in Rome, Italy, has revealed the long-term benefits of vagus nerve stimulation (VNS) in managing drug-resistant epilepsy. A study involving 105 adult patients found that 80.8% of participants experienced significant reductions in seizure frequency over an average follow-up period of
Anticonvulsants
Researchers at University College London (UCL) have made a significant breakthrough in the treatment of epilepsy, a neurological disorder that affects millions of people worldwide. According to a new study published in the Journal of Seizure, a promising strategy to overcome drug-resistance in epilepsy involves the co-administration of a P-glycoprotein
