Drugs
Scientists in Taipei, Taiwan, have discovered that heme oxygenase-1 (HO-1), an enzyme with multiple vasoprotective functions, plays a crucial role in promoting the mobilization of circulating endothelial progenitor cells (EPCs) and enhancing re-endothelialization after vascular injury. The study, published in the Journal of Thrombosis and Haemostasis, found that systemic HO-1
Drugs
Recent research from the United States has shown that a specific inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone (AAPF(CMK)), exhibits anticarcinogenic activity in various model systems. This compound has been found to be relatively selective for a nuclear protease and has substantial effects on the growth of tumorigenic human papillomavirus (HPV)-infected
Drugs
A recent study published in Molecular Cancer Therapeutics has highlighted the potential of Src tyrosine kinase as a target for anticancer therapy, particularly in pancreatic cancer. Researchers in the United States investigated the in vivo efficacy and pharmacodynamic effects of bosutinib, a Src/Abl inhibitor, using a panel of human
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Researchers from the Medical University of South Carolina have discovered a new approach to treating malignant peripheral nerve sheath tumors (MPNST), a disease that affects approximately 10% of neurofibromatosis type-1 patients and is a major contributing factor to their mortality and morbidity. The study found that small hyaluronan oligosaccharides can
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Scientists in Seoul, South Korea, have made significant discoveries about the role of neurosteroids in modulating pain transmission in the spinal cord. The researchers investigated the effects of dehydroepiandrosterone sulphate (DHEAS) and its non-sulphated form, DHEA, on nociceptive signalling at the spinal cord level. Their findings suggest that intrathecally injected
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Recent research published in the New U.K. Journal of Medicine has revealed the potential of olaparib, a novel PARP inhibitor, in treating cancers caused by BRCA1 or BRCA2 mutations. The clinical evaluation conducted on 60 patients, including 22 carriers of BRCA1 or BRCA2 mutations, showed that olaparib inhibited PARP
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A study conducted in Prague, Czech Republic, discovered that a deficiency of dihydropyrimidine dehydrogenase (DPD) is linked to severe fluoropyrimidine (FP) toxicity in cancer patients. Researchers at Charles University analyzed 68 patients who experienced high-grade gastrointestinal and/or hematological toxicity after receiving FP treatment and found no evidence of large
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A team of researchers from the University of Washington has made a significant breakthrough in the treatment of prostate cancer by developing an orally bioavailable form of the GnRH antagonist acyline. The findings, published in Cancer Chemotherapy and Pharmacology, demonstrate that oral administration of GIPET(A [R])-enhanced acyline can
Drugs
A recent study from the University of Manitoba's Department of Medical Microbiology in Winnipeg, Canada, has demonstrated the superior pharmacodynamic activity of ceftobiprole compared to vancomycin against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate Staphylococcus aureus (VISA), and vancomycin-resistant Staphylococcus aureus (VRSA) in an in vitro model. The study, published
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Researchers from Tohoku University, Department of Pharmacology, have documented aberrant behaviors related to learning and memory in olfactory bulbectomized (OBX) mice. The impairment of long-term potentiation (LTP) of hippocampal CA1 regions from OBX mice was associated with down-regulation of CaM kinase II (CaMKII) and protein kinase C (PKC) activities. However,
Drugs
Recent research from the United States has discovered that protease inhibitors (PIs), a class of antiretroviral drugs used to treat HIV/AIDS, are cleared from the body at a faster rate in pregnant women. Specifically, the apparent oral clearance of PIs is increased by 3.14-fold in pregnant women compared
Drugs
Researchers in the United States have discovered novel effects of basal signaling by a G protein-coupled receptor (GPCR) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) on the migration of endothelial cells. The study found that basal signaling by KSHV-GPCR inhibits the migration of endothelial cells in two systems, movement
