Drugs
Scientists in Singapore have published new data on the effects of angiotensin-converting enzyme inhibitors on mouse kidney growth arrest specific-6 (GAS-6) protein and the AXL subfamily of receptor tyrosine kinases. The study found that chronic dosing with captopril up-regulated GAS-6 and AXL expression in the kidneys of treated mice, with
Drugs
Researchers in Mainz, Germany conducted a comparative study on the pharmacokinetics/pharmacodynamics properties and patient preference for insulin aspart administered via the FlexPen and pulmonary human insulin delivered via the Exubera device. The study involved 12 patients with diabetes, who received 11 units of insulin from either the FlexPen or
Drugs
Researchers at the University Hospital in Netherlands have reported a case of trastuzumab-induced pneumonitis in a female patient with HER2-positive metastatic breast cancer. The patient developed pulmonary infiltrates and pleural effusion dyspnea after several months of trastuzumab treatment, despite having been treated without complications with a combination of docetaxel, trastuzumab,
Drugs
Researchers in Xian, People's Republic of China, have discovered that eukaryotic initiation factor eIF4E plays a crucial role in the malignant transformation, progression, and chemoresistance of human breast carcinoma. The overexpression of this gene has been found in various human malignancies, including breast carcinoma. A study published in
Drugs
Recent research from University of London, Imperial College, has developed a new system analysis modeling approach to characterize drug distribution in tissues based on human positron emission tomography (PET) data. This innovative method, applied to temozolomide, an important alkylating agent used in the treatment of brain tumors, has shown promising
Drugs
During pregnancy, women's bodies undergo numerous changes that affect energy balance and metabolism. Research published in the Journal of Physiology and Pharmacology has shed light on the role of acylation stimulating protein (ASP) in pregnancy weight gain. ASP is a protein secreted by adipocytes that plays a crucial
Drugs
Scientists investigating the effects of trovafloxacin (TVX), a fluoroquinolone antibiotic, have uncovered a complex interplay of mechanisms leading to liver injury. The research, published in the Journal of Pharmacology and Experimental Therapeutics, reveals that TVX therapy, in combination with lipopolysaccharide (LPS), triggers an inflammatory cascade that culminates in tumor necrosis
Drugs
Scientists at Cornell University's Department of Pharmacology have published a groundbreaking report detailing the differential effects of serine proteases on the migration of normal and tumor cells. This research has significant implications for understanding tumor progression and metastasis, as well as the potential therapeutic applications of proteases. The
Drugs
Researchers at the University of Louvain in Brussels, Belgium have made a significant discovery about the heat shock protein 90 (Hsp90) and its role in cancer cell death. They found that an oxidative stress generated by ascorbate/menadione redox cycling leads to Hsp90 cleavage, resulting in the degradation of critical
Drugs
A recent phase I study published in Clinical Cancer Research has provided valuable insights into the pharmacokinetics of erlotinib, a protein kinase inhibitor, in children with newly diagnosed high-grade glioma. The study aimed to estimate the maximum-tolerated dose (MTD) of erlotinib when administered concurrently with radiotherapy and to describe the
Drugs
Researchers from the University of Kansas have conducted a study to investigate the molecular requirements necessary for Bak activation during intrinsic apoptotic cell death. The study, published in the Journal of Biological Chemistry, found that caspase-mediated Bak activation and cytochrome c release are critical events in the intrinsic apoptotic pathway.
Drugs
The emergence of non-susceptible strains of methicillin-resistant Staphylococcus aureus (MRSA), including heterogeneously vancomycin-intermediate S. aureus (hVISA), has led to concerns about the effectiveness of current treatments. Researchers in the United States conducted a study to evaluate the efficacy of vancomycin and daptomycin against vancomycin-susceptible MRSA and hVISA in a pharmacokinetic/
